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Table 1 Baseline characteristics

From: Association between diuretics and successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury

Clinical variables

CRRT discontinuation group (n = 517)

HD initiation group (n = 310)

CRRT re-initiation group (n = 349)

p value

Age (years)

62.1 (15.2)

61.0 (14.9)

61.9 (14.8)

0.613

Male

330 (63.8%)

197 (63.5%)

222 (63.6%)

0.996

Comorbidity

 Hypertension

185 (35.8%)

142 (45.8%)

95 (27.2%)

< 0.001cde

 Diabetes mellitus

136 (26.3%)

94 (30.3%)

81 (23.2%)

0.118

 Ischemic heart disease

36 (7.0%)

17 (5.5%)

17 (4.9%)

0.408

 Liver cirrhosis

31 (6.0%)

24 (7.7%)

34 (9.7%)

0.123

 Heart failure

22 (4.3%)

19 (6.1%)

15 (4.3%)

0.420

At CRRT initiation

 BUN (mmol/L)

30.0 (12.1)

21.8 (10.8)

19.9 (10.8)

0.106

 Serum creatinine (μmol/L)

228.1 (145.0–351.8)

353.6 (223.7–548.1)

225.4 (147.6–337.7)

< 0.001ac

 Urine output (mL/day)

570 (180–1308)

116 (0–361)

244 (32–835)

< 0.001abc

Day −1 before CRRT discontinuation

 BUN (mmol/L)

13.4 (9.1)

13.6 (7.9)

13.4 (7.75)

0.924

 Serum creatinine (μmol/L)

134.4 (91.9–209.5)

191.8 (122.9–302.3)

143.2 (99.0–224.5)

< 0.001ac

 Urine output (mL/day)

565 (252–1250)

45 (5–190)

60 (10–289)

< 0.001ab

 Mean blood pressure (mmHg)

79.4 (15.1)

78.5 (15.4)

79.6 (15.0)

0.631

 Vasopressor use

342 (66.2%)

202 (65.2%)

241 (69.1%)

0.530

Duration of CRRT (days)

3.4 (2.6)

4.8 (5.1)

4.8 (5.0)

< 0.001ab

Use of diuretics after CRRT

388 (75.0%)

129 (41.6%)

102 (29.2%)

< 0.001abc

  1. Continuous variables following a normal distribution are expressed as mean (standard deviation) or median (interquartile range). Categorical variables are expressed as number (percentage). One-way analysis of variance followed by the Bonferroni correction or the Kruskal-Wallis test followed by the Mann-Whitney test was performed for analysis of the continuous renal replacement therapy (CRRT) discontinuation group versus the hemodialysis (HD) initiation group versus the CRRT re-initiation group. Categorical variables were compared using the χ2 test
  2. Abbreviations: BUN blood urea nitrogen, Day − 1 one day before CRRT discontinuation
  3. ap ≤ 0.001 for CRRT discontinuation group versus HD initiation group
  4. bp ≤ 0.001 for CRRT discontinuation group versus CRRT re-initiation group
  5. cp ≤ 0.001 for HD initiation group versus CRRT re-initiation group
  6. dp ≤ 0.01 for CRRT discontinuation group versus HD initiation group
  7. ep ≤ 0.01 for CRRT discontinuation group versus CRRT re-initiation group
  8. fp ≤ 0.01 for HD initiation group versus CRRT re-initiation group
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Critical Care

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