|
Clinical variables
|
CRRT discontinuation group (n = 517)
|
HD initiation group (n = 310)
|
CRRT re-initiation group (n = 349)
|
p value
|
|---|
|
Age (years)
|
62.1 (15.2)
|
61.0 (14.9)
|
61.9 (14.8)
|
0.613
|
|
Male
|
330 (63.8%)
|
197 (63.5%)
|
222 (63.6%)
|
0.996
|
|
Comorbidity
|
|
Hypertension
|
185 (35.8%)
|
142 (45.8%)
|
95 (27.2%)
|
< 0.001cde
|
|
Diabetes mellitus
|
136 (26.3%)
|
94 (30.3%)
|
81 (23.2%)
|
0.118
|
|
Ischemic heart disease
|
36 (7.0%)
|
17 (5.5%)
|
17 (4.9%)
|
0.408
|
|
Liver cirrhosis
|
31 (6.0%)
|
24 (7.7%)
|
34 (9.7%)
|
0.123
|
|
Heart failure
|
22 (4.3%)
|
19 (6.1%)
|
15 (4.3%)
|
0.420
|
|
At CRRT initiation
|
|
BUN (mmol/L)
|
30.0 (12.1)
|
21.8 (10.8)
|
19.9 (10.8)
|
0.106
|
|
Serum creatinine (μmol/L)
|
228.1 (145.0–351.8)
|
353.6 (223.7–548.1)
|
225.4 (147.6–337.7)
|
< 0.001ac
|
|
Urine output (mL/day)
|
570 (180–1308)
|
116 (0–361)
|
244 (32–835)
|
< 0.001abc
|
|
Day −1 before CRRT discontinuation
|
|
BUN (mmol/L)
|
13.4 (9.1)
|
13.6 (7.9)
|
13.4 (7.75)
|
0.924
|
|
Serum creatinine (μmol/L)
|
134.4 (91.9–209.5)
|
191.8 (122.9–302.3)
|
143.2 (99.0–224.5)
|
< 0.001ac
|
|
Urine output (mL/day)
|
565 (252–1250)
|
45 (5–190)
|
60 (10–289)
|
< 0.001ab
|
|
Mean blood pressure (mmHg)
|
79.4 (15.1)
|
78.5 (15.4)
|
79.6 (15.0)
|
0.631
|
|
Vasopressor use
|
342 (66.2%)
|
202 (65.2%)
|
241 (69.1%)
|
0.530
|
|
Duration of CRRT (days)
|
3.4 (2.6)
|
4.8 (5.1)
|
4.8 (5.0)
|
< 0.001ab
|
|
Use of diuretics after CRRT
|
388 (75.0%)
|
129 (41.6%)
|
102 (29.2%)
|
< 0.001abc
|
- Continuous variables following a normal distribution are expressed as mean (standard deviation) or median (interquartile range). Categorical variables are expressed as number (percentage). One-way analysis of variance followed by the Bonferroni correction or the Kruskal-Wallis test followed by the Mann-Whitney test was performed for analysis of the continuous renal replacement therapy (CRRT) discontinuation group versus the hemodialysis (HD) initiation group versus the CRRT re-initiation group. Categorical variables were compared using the χ2 test
- Abbreviations: BUN blood urea nitrogen, Day − 1 one day before CRRT discontinuation
- ap ≤ 0.001 for CRRT discontinuation group versus HD initiation group
- bp ≤ 0.001 for CRRT discontinuation group versus CRRT re-initiation group
- cp ≤ 0.001 for HD initiation group versus CRRT re-initiation group
- dp ≤ 0.01 for CRRT discontinuation group versus HD initiation group
- ep ≤ 0.01 for CRRT discontinuation group versus CRRT re-initiation group
- fp ≤ 0.01 for HD initiation group versus CRRT re-initiation group
