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Table 7 Relationship between epidemiological and treatment factors and in-hospital mortality among patients with severe sepsis using a generalized estimating equation model (n = 952)

From: Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study

Characteristics

Odds_(95%CI)

Age at admission, years

1.02_(1.01–1.04)

Male sex

0.81_(0.57–1.14)

Body mass index

1_(0.97–1.04)

ADL

0.88_(0.58–1.32)

Admission source

 ED

reference

 w/o ED (transfer or other department)

1.12_(0.78–1.62)

 ICU

1.99_(0.91–4.36)

CCI

1.2_(1.09–1.32)

Septic shock

 Yes

1.01_(0.63–1.62)

Suspected site of infection

 Lung

reference

 Abdomen

0.54_(0.35–0.85)

 Urinary tract

0.22_(0.12–0.41)

 Soft tissue

0.73_(0.4–1.33)

 Others

1.16_(0.7–1.89)

SOFA score

1.18_(1.12–1.24)

Positivity of blood cultures (bacteremia)

1.16_(0.82–1.64)

Fluid resuscitation protocola

 Not achievement

reference

 Achievement

1.14_(0.72–1.82)

 Not indicated

1.06_(0.59–1.91)

Broad-spectrum antibiotic use

1.04_(0.66–1.64)

  1. Missing data: body mass index = 26, admission source = 2, ADL = 2, positivity of blood cultures = 7, Sepsis-related Organ Failure Assessment (SOFA) = 183, fluid resuscitation protocol = 9, broad-spectrum antibiotic use = 5
  2. ED emergency department, ICU intensive care unit, CCI Charlson Comorbidity Index, ADL activities of daily living
  3. aCrystalloid fluid bolus (30 mg/kg) delivered if it was indicated in the bundle in Surviving Sepsis Campaign Guidelines 2012