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Table 3 The commonly used adsorption cartridges and their prescriptions

From: Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the pitfalls

  Toraymyxin Cytosorb Oxiris LPS adsorber HA 330
Composition Polymyxin B-immobilized fiber blood-purification column Porous polymer beads AN69-based membrane, surface treated with PEI and grafted with heparin Synthetic polypeptide bound to porous polyethylene discs Styrene divinylbenzene copolymers
Indication Severe sepsis and septic shock Severe sepsis and septic shock
Cardiac surgery with SIRS
Severe sepsis and septic shock Severe sepsis and septic shock Severe sepsis and septic shock
Toxins removed Endotoxins Cytokines/chemokines
Anaphylatoxins
Myoglobin
Free hemoglobin
Bilirubin/bile acids
Toxins/metals
Drugs
Endotoxin
Cytokines
Endotoxins Cytokines
Complements
Free hemoglobin
Prescription 2-h session daily for 2 consecutive days Up to 24-h therapy daily for 2–7 consecutive days Prescribed dose > 35 ml/kg/h (60% convective).
Filter replacement after 24 h or if there is no reduction in VP dose by 50%. Treatment should be stopped if VP are reduced by > 50% or after 3 days of treatment in case of no-response
2–6 h.
One session is usually sufficient to achieve improvement. Repeated procedures can be performed
2–6 h daily for 2 days
Blood flow rate (ml/min) 80–120 150–700 100–450 150 ± 50 100–300
Anticoagulation Heparin Heparin or citrate Heparin Heparin Heparin or citrate
Additional features Polymyxin B antimicrobial effect Largest surface area Lower risk of thrombogenicity by adsorbing antithrombin-III from the blood   
  1. CRRT continuous renal replacement therapy, LPS lipopolysaccharides, PEI polyethyleneimine, SIRS systemic inflammatory response syndrome, VP vasopressors