The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis

Table 1 Clinical characteristics of patients with sepsis and healthy controls

Variable	Sepsis (n = 885) Number (percent)	Control (n = 1101) Number (percent)	P value
Demographics
Age, years, mean ± SEM	60.05 ± 0.58	59.02 ± 0.52	0.189
Male/female, n	584/301	688/413	0.106
Sepsis status, n (%)
Sepsis subtype	165 (18.6)	N.A
Severe sepsis	364 (41.2)	N.A
Septic shock	356 (40.2)	N.A
Source of infection, n (%)
Respiratory tract infection	629 (71.1)	N.A
Primary bloodstream infection	126 (14.2)	N.A
Abdominal infection	193 (21.8)	N.A
Urinary tract infection	45 (5.1)	N.A
Catheter-associated infection	51 (5.8)	N.A
Brain	37 (4.2)	N.A
Others	60 (6.8)	N.A
Infection type, n (%)
Gram-positive	162 (18.3)	N.A
Gram-negative	417 (47.1)	N.A
Mixed Gram-negative and Gram-positive	163 (18.4)	N.A
Fungus	136 (15.3)	N.A
Polymicrobial	194 (21.9)	N.A
Negative blood culture	59 (6.7)	N.A
Pathogenic bacteria, n (%)
Acinetobacter baumannii	220 (24.9)	N.A
Monilia albican	47 (5.3)	N.A
Yeast sample sporphyte	34 (3.8)	N.A
Aspergillus	30 (3.4)	N.A
Klebsiella pneumoniae	66 (7.5)	N.A
Pseudomonas aeruginosa	109 (12.3)	N.A
Staphylococcus aureus	60 (6.8)	N.A
Escherichia coli	94 (10.6)	N.A
Others	169 (19.1)	N.A
APACHE II score	25.6 ± 5.7	N.A
Mortality, 28 days, n (%)	216 (24.4)	N.A

Continuous data are expressed as the mean ± SEM
N.A not applicable, APACHE II Acute Physiology and Chronic Health Evaluation II

ISSN: 1364-8535