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Fig. 8 | Critical Care

Fig. 8

From: The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis

Fig. 8

IL-27 enhances lipolysaccharide (LPS)-induced pro-inflammatory cytokine expression and cell apoptosis. The supernatant concentrations of TNF-α, IL-6, and IL-1β from THP-1 cells incubated with medium alone, IL-27 (100 ng/mL), LPS (500 ng/mL) or a combination of both for 8 and 16 h (a, b, c); Evaluation of apoptosis of THP-1 cells incubated with medium, IL-27 (100 ng/mL), LPS (500 ng/mL) or a combination of both for 16 h using annexin-V-fluorescein isothiocyanate (FITC)/propium iodide staining and flow cytometry (d, e). Bar graphs indicate the mean ± SEM for a minimum of three experiments, each performed in triplicate

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Critical Care

ISSN: 1364-8535