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Table 1 Antimicrobial utilization per antimicrobial class and per infection probability

From: A complete and multifaceted overview of antibiotic use and infection diagnosis in the intensive care unit: results from a prospective four-year registration

 

DOT (%)

DOT/1000 patient days

DOT (% of total DOT/antibiotic class)

Infection present

Prophylactic treatment

High probability

Moderate probability

Low probability

 

Antibacterial class

 Aminoglycosides

474 (1.0)

10.0

388 (81.8)

67 (14.1)

5 (1.1)

6 (1.3)

 Ansamycins (rifampicin)

268 (0.5)

5.7

230 (85.8)

9 (3.4)

13 (4.9)

15 (5.6)

 Carbapenems

4488 (9.1)

94.7

3438 (76.6)

697 (15.5)

221 (4.9)

110 (2.5)

 1st gen. cephalosporins

2939 (6.0)

62.0

–

–

–

2939 (100)

 2nd gen. cephalosporins

1192 (2.4)

25.1

398 (33.4)

324 (27.2)

169 (14.2)

301 (25.3)

 3rd gen. cephalosporins

1955 (4.0)

41.2

1343 (68.7)

400 (20.5)

143 (7.3)

63 (3.2)

 Fluoroquinolones

5385 (11)

113.6

3268 (60.7)

1285 (23.9)

367 (6.8)

448 (8.3)

 Folate pathway inhibitor

3105 (6.3)

65.5

896 (28.9)

319 (10.3)

142 (4.6)

1747 (56.3)

 Glycopeptides

2966 (6.0)

62.6

2163 (72.9)

438 (14.8)

172 (5.8)

169 (5.7)

 Glycylcyclines

319 (0.6)

6.7

242 (75.9)

63 (19.7)

11 (3.4)

2 (0.6)

 Lincosamides

806 (1.6)

17.0

564 (70.0)

140 (17.4)

42 (5.2)

60 (7.4)

 Macrolides

1421 (2.9)

30.0

834 (58.7)

215 (15.1)

84 (5.9)

284 (20.0)

 Monobactams

150 (0.3)

3.2

33 (22.0)

28 (18.7)

10 (6.7)

79 (52.7)

 Nitrofurans

59 (0.1)

1.2

19 (32.2)

16 (27.1)

7 (11.9)

17 (28.8)

 Nitroimidazoles

1289 (2.6)

27.2

976 (75.7)

147 (11.4)

61 (4.7)

92 (7.1)

 Oxazolidinones

1780 (3.6)

37.6

1434 (80.6)

212 (11.9)

53 (3.0)

69 (3.9)

 Penicillins

1504 (3.1)

31.7

1212 (80.6)

188 (12.5)

86 (5.7)

15 (1.0)

 Non-anti-pseudomonal penicillins + beta-lactamase inhibitor

8136 (16.5)

171.6

3267 (40.2)

1605 (19.7)

660 (8.1)

2588 (31.8)

 Anti-pseudomonal penicillins + beta-lactamase inhibitor

10,342 (21.0)

218.2

6405 (61.9)

2292 (22.2)

808 (7.8)

800 (7.7)

 Phosphonic acids

27 (0.1)

0.6

3 (11.1)

17 (63.0)

6 (22.2)

1 (3.7)

 Polymyxins

469 (1.0)

9.9

311 (66.3)

97 (20.7)

19 (4.1)

42 (9.0)

 Tetracyclines

95 (0.2)

2.0

82 (86.3)

1 (1.1)

1 (1.1)

11 (11.6)

 Total antibacterial

49,169 (100)

1037.3

27,506 (55.9)

8560 (17.4)

3080 (6.3)

9858 (20.0)

Antifungal class

 Azoles

7684 (83.1)

162.1

2123 (27.6)

415 (5.4)

222 (2.9)

4809 (62.6)

 Echinocandins

1354 (14.6)

28.6

1022 (75.5)

176 (13.0)

93 (6.9)

56 (4.1)

 Polyenes

206 (2.2)

4.3

138 (67.0)

37 (18.0)

29 (14.1)

–

 Total antifungal

9244 (100)

195.0

3283 (35.5)

628 (6.8)

344 (3.7)

4865 (52.6)

Total

58,413 (100)

1232.3

30,789 (52.7)

9188 (15.7)

3424 (5.9)

14,723 (25.2)

  1. DOT days of therapy, gen. generation