Skip to main content

Table 4 Indices of illness severity among the cortisol high/low and glucocorticoid receptor alpha high/low groups

From: The glucocorticoid receptor and cortisol levels in pediatric septic shock

 

High/High

High/Low

Low/High

Low/Low

Day 1 relative cortisol level/relative GCR alpha level

 Number

20

26

13

30

 Rate of complicated course

30%

27%

8%

23%

 Median PRISM, (IQR)

13 (8–19)

13 (7–18)

9 (4–11)

10 (7–14)

 Maximum organ failures, median (IQR)

2 (2–3)

2 (1–3)

2 (1–3)

2 (1–2)

 Median PICU-free days, (IQR)

20 (15–26)

23 (9–26)

24 (21–27)

24 (20–26)

 Median vasopressor-free days, (IQR)

26 (22–27)

26 (23–27)

27 (25–27)

26 (25–27)

Day 3 relative cortisol level/relative GCR alpha level

 N

12

12

15

12

 Rate of complicated course

33%

75%a

13%

33%

 Median PRISM, (IQR)

13 (10–14)

20 (14–24)b

8 (6–12)

10 (8–14)

 Maximum organ failures, median (IQR)

2 (2–3)

3 (2–4)b

2 (2–2)

2 (2–2)

 Median PICU-free days, (IQR)

20 (17–25)

0 (0–13)c

21 (10–25)

22 (9–25)

 Median vasopressor-free days, (IQR)

25 (23–27)

18 (0–24)c

25 (25–27)

25 (24–26)

  1. aP <0.05, chi-squared, 3 degrees of freedom
  2. bP <0.05, versus low/high and low/low groups, analysis of variance (ANOVA) on ranks
  3. cP <0.05, versus all other groups, ANOVA on ranks
  4. Abbreviations: GCR glucocorticoid receptor, IQR interquartile range, PICU pediatric intensive care unit, PRISM Pediatric Risk of Mortality