Table 1 Demographic and clinical variables of the study cohort

N

35

17

23

89

Median age, years (IQR)

2.0 (0.6–5.0)

5.7 (3.3–10.8)

6.6 (3.8–14.3)^a

7.4 (1.7–14.2)^a

Males, n (%)

24 (69)

8 (47)

11 (48)

53 (60)

Median baseline cortisol, μg/dL (IQR)

15 (9–21)

27 (14–35)

19 (10–30)

25 (13–49)^a

Mortality, n (%)

–

2 (12)

0 (0)

6 (8)

Complicated course, n (%)

–

2 (12)

0 (0)

21 (24)^b

Median PRISM, (IQR)

–

4 (3–11)

5 (3–8)

11 (7–15)^c

Gram-positive bacteria, n (%)

–

–

10 (43)

15 (17)

Gram-negative bacteria, n (%)

–

–

0 (0)

19 (21)

Other organism, n (%)^d

–

–

0 (0)

8 (9)

Culture negative, n (%)

–

–

13 (57)

47 (53)

Comorbidity, n (%)

–

14 (82)

16 (70)

60 (67)

Malignancy, n (%)

–

0 (0)

3 (13)

14 (16)

Immunosuppression, n (%)^e

–

1 (6)

3 (13)

20 (22)

Bone marrow transplantation, n (%)

–

0 (0)

1 (4)

13 (15)

Received corticosteroids, n (%)

–

2 (12)

7 (30)

37 (42)