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Table 2 Rectal colonization with resistant Gram-negative bacteria at and after ICU discharge and number of resistance phenotypes (to ceftazidime, tobramycin, colistin, meropenem and ciprofloxacin)

From: Carriage of antibiotic-resistant Gram-negative bacteria after discontinuation of selective decontamination of the digestive tract (SDD) or selective oropharyngeal decontamination (SOD)

 

Number of patients colonized with ARGNB at ICU discharge

Number of patients acquiring colonization with ARGNB after ICU discharge

SDD (n = 507)

SOD (n = 489)

p value*

SDD (n = 426)

SOD (n = 409)

p value*

At least one AR-GNB

 ICU A

8/154 (5.2%)

29/271 (10.7%)

0.05

14/134 (10.4%)

38/224 (17.0%)

0.09

 ICU B

6/115 (5.2%)

38/124 (30.6%)

< 0.0001

9/95 (9.5%)

16/96 (16.7%)

0.14

 ICU C

8/238 (3.4%)

20/94 (21.3%)

< 0.0001

18/197 (9.1%)

10/89 (11.2%)

0.6

 All

22/507 (4.3%)

87/489 (17.8%)

< 0.0001

41/426 (9.6%)

64/409 (15.6%)

0.01

Different ARGNB

23

97

< 0.0001

66

90

0.02

E.coli

10

46

 

20

36

 

Enterobacter sp.

1

11

 

8

15

 

K. pneumoniae

1

9

 

6

4

 

P. aeruginosa

3

15

 

6

15

 

 other

8

16

 

26

20

 

Resistance phenotypes

 Ceftazidime

9

46

 

21

27

 

 Ciprofloxacin

11

40

 

12

29

 

 Tobramycin

17

33

 

23

36

 

 Meropenem

0

3

 

1

3

 

 Colistin

5

10

 

7

11

 

 ESBL

7

60

 

20

24

 
  1. ARGNB antibiotic resistant Gram-negative bacteria, SDD selective decontamination of the digestive tract, SOD selective oropharyngeal decontamination, ESBL extended spectrum beta-lactamase
  2. *p value by Chi square analysis for difference between SOD and SDD