Net ultrafiltration intensity and mortality in critically ill patients with fluid overload

Murugan, Raghavan; Balakumar, Vikram; Kerti, Samantha J.; Priyanka, Priyanka; Chang, Chung-Chou H.; Clermont, Gilles; Bellomo, Rinaldo; Palevsky, Paul M.; Kellum, John A.

doi:10.1186/s13054-018-2163-1

Critical Care

Table 5 Sensitivity and subgroup analyses of net ultrafiltration intensity and mortality

From: Net ultrafiltration intensity and mortality in critically ill patients with fluid overload

Characteristic	Net ultrafiltration intensity	Adjusted odds ratio (95% CI)^a	p value
Sensitivity analysis
UF^NET up to 72 h after RRT initiation^b	High vs low	0.56 (0.35–0.88)	0.013
UF^NET up to 72 h after RRT initiation^b	Moderate vs low	1.10 (0.58–2.11)	0.76
Alternative UF^NET threshold^c	High vs low	0.63 (0.41–0.97)	0.038
Alternative UF^NET threshold^c	Moderate vs low	0.91 (0.53–1.58)	0.74
Alternative UF^NET threshold^d	High vs low	0.58 (0.34–0.99)	0.044
Alternative UF^NET threshold^d	Moderate vs low	0.66 (0.43–1.01)	0.053
Alternative UF^NET threshold^e	High vs low	0.61 (0.39–0.97)	0.0371
Alternative UF^NET threshold^e	Moderate vs low	0.69 (0.45–1.07)	0.096
Subgroup analysis
UF^NET among subgroup of patients with cumulative FB > 20% before RRT^f	High vs low	0.52 (0.26–1.05)	0.07
	Moderate vs low	0.74 (0.29–1.84)	0.51
Alternative UF^NET threshold among subgroup of patients who only received CRRT^g	High vs low	0.41 (0.24–0.71)	0.0013
	Moderate vs low	0.68 (0.39–1.18)	0.17

CI confidence interval, UF^NET net ultrafiltration, RRT renal replacement therapy, FB fluid balance, CRRT continuous renal replacement therapy, FO fluid overload, ICU intensive care unit
^aAdjusted for differences in age, sex, race, body mass index, history of liver disease and sequela from liver disease, admission for liver transplantation, admission for surgery, baseline glomerular filtration rate, Acute Physiology and Chronic Health Evaluation III score, presence of sepsis, use of mechanical ventilation, percentage of FO before initiation of RRT, oliguria before initiation of RRT, time to initiation of RRT from ICU admission, mean arterial pressure on first day of RRT initiation, cumulative vasopressor dose and fluid balance during RRT, first RRT modality and duration of RRT
^bUF^NET intensity calculated using RRT duration of 72 h as a cutoff value in 1075 patients
^cThreshold for low, moderate and high UF^NET varied as follows in 1075 patients: low, < 15 ml/kg/day; moderate, 15–20 ml/kg/day; and high, > 20 ml/kg/day
^dThreshold for low, moderate and high UF^NET varied as follows in 1075 patients: low, < 25 ml/kg/day; moderate, 25–30 ml/kg/day; and high, > 30 ml/kg/day
^eThreshold for low, moderate and high UF^NET based on stratifying the cohort of 1075 patients into tertiles: low, ≤ 16.7 ml/kg/day; moderate, 16.7 to ≤ 27.7 ml/kg/day; and high, > 27.7 ml/kg/day
^fUF^NET calculated within subgroup of 465 patients with cumulative FB > 20% before RRT initiation
^gThreshold for low, moderate and high UF^NET varied among subgroup of 487 patients who only received CRRT as follows: low, < 0.5 ml/kg/h; moderate, 0.5–1.0 ml/kg/h; and high, > 1 ml/kg/h

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