Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Table 4 Multivariable analysis for hospital mortality in patients with ARDS

Variable	Odds ratio (95% CI)	p value
Diabetes mellitus diagnosis	1.15 (0.93, 1.42)	0.19
Age (years)	1.02 (1.02, 1.03)	< 0.0001
Non-respiratory SOFA (adjusted for missing values)	1.12 (1.10, 1.49)	< 0.0001
BMI (kg/m²)	0.98 (0.96, 0.99)	< 0.0001
Chronic cardiac failure (NYHA III-IV)	1.36 (1.04, 1.79)	0.03
Haematologic neoplasm	4.05 (2.59, 6.36)	< 0.0001
Active neoplasm	1.91 (1.43, 2.56)	< 0.0001
Immunosuppression	1.56 (1.19, 2.05)	0.001
Respiratory rate (breaths/min)	1.03 (1.02, 1.04)	< 0.0001
Baseline PaO₂:FiO₂ ratio (mmHg)	0.998 (0.997, 0.999)	0.007
Baseline PEEP (cmH₂O)	0.95 (0.93, 0.98)	0.003
Baseline peak inspiratory pressure (cmH₂O)	1.01 (1.00, 1.02)	0.05
Blood pH	0.18 (0.09, 0.39)	< 0.0001

Analysis based on data from 2633 observations
Abbreviations: BMI body mass index, CI confidence interval, SOFA Sequential Organ Failure Assessment, NYHA New York heart association functional classification, PaO₂:FiO₂ ratio of partial pressure of arterial blood oxygen content to inspired fraction of oxygen, PEEP positive end-expiratory pressure