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Table 1 Baseline characteristics of patients with AHRF (stratified by presence of diabetes)

From: Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

  Overall (N = 4107) Diabetic (N = 913) Non-diabetic (N = 3194) p value (Diabetic vs. non-diabetic)
Age (years) 61.7 ± 16.7 66.6 ± 13.1 60.3 ± 17.4 < 0.0001
Male – N (%) 2547 (62.0) 575 (63.0) 1972 (61.7) 0.50
BMI (kg/m2)a 27.5 ± 8.3 30.4 ± 11.7 26.6 ± 6.9 < 0.0001
Non-pulmonary SOFA score (adjusted for missing values)b 6.1 ± 4.1 6.2 ± 4.2 6.1 ± 4.0 0.39
ARDS risk factors – N (%)     0.07
 Pulmonary 2295 (55.9) 511 (52.0) 1784 (55.9)  
 Non-pulmonary 833 (20.3) 174 (19.1) 659 (20.6)  
 Pulmonary and non-pulmonary 559 (13.6) 115 (12.6) 444 (13.9)  
 No risk factor 420 (10.2) 113 (12.4) 307 (9.6)  
Co-morbidities – N (%)     
 No co-morbidity other than diabetes mellitus 1958 (47.7) 343 (37.6) 1615 (50.6) < 0.0001
 Chronic liver failure 161 (3.9) 33 (3.6) 128 (4.0) 0.37
 Chronic renal failure 428 (10.4) 205 (22.5) 227 (7.0) < 0.0001
 Chronic cardiac failure (NYHA III-IV) 428 (10.4) 156 (17.1) 272 (8.5) < 0.0001
 COPD or home ventilation 989 (24.1) 294 (32.2) 695 (21.8) < 0.0001
 Active neoplasm 368 (9.0) 61 (6.7) 307 (9.6) 0.006
 Immunosuppression 453 (11.0) 73 (8.0) 380 (11.9) 0.0009
 Haematologic neoplasm 170 (4.1) 22 (2.4) 148 (4.6) 0.003
 Active neoplasm/immunosuppression/haematologic neoplasm 820 (20.0) 134 (14.7) 686 (21.5) < 0.0001
Baseline ventilator variables     
 PaO2:FiO2 ratio (mmHg)c 167.5 ± 67.8 169.2 ± 67.1 167.0 ± 68.0 0.35
 Tidal volume (ml/kg PBW)d 7.8 ± 2.2 8.0 ± 2.4 7.7 ± 2.1 0.05
 Plateau pressure (cmH2O)e 22.4 ± 5.9 23.3 ± 5.6 22.1 ± 6.0 0.001
 PEEP (cmH2O)f 7.8 ± 3.1 7.8 ± 3.1 7.8 ± 3.1 0.76
 Peak inspiratory pressure (cmH2O)g 24.8 ± 8.7 25.3 ± 8.8 24.7 ± 8.7 0.05
 Respiratory rate (breaths/min)h 21.2 ± 8.1 20.9 ± 6.7 21.3 ± 8.4 0.42
 Blood pHi 7.34 ± 0.12 7.33 ± 0.13 7.34 ± 0.12 0.06
 PaCO2 (mmHg)j 45.8 ± 15.6 46.0 ± 15.6 45.7 ± 15.6 0.51
 Bicarbonate (mmol/L)k 23.6 ± 6.8 23.4 ± 7.1 23.6 ± 6.7 0.36
  1. Data presented as mean ± standard deviation unless otherwise stated
  2. Abbreviations: AHRF acute hypoxaemic respiratory failure ARDS acute respiratory distress syndrome, BMI body mass index, COPD chronic obstructive pulmonary disease, NYHA New York heart association functional classification, PaCO2 partial pressure of carbon dioxide in arterial blood, PBW predicted body weight, PEEP positive end-expiratory pressure, SOFA sequential organ failure assessment
  3. a872 diabetic, 3010 non-diabetic, 3882 patients overall
  4. b908 diabetic, 3168 non-diabetic, 4076 patients overall
  5. c911 diabetic, 3175 non-diabetic, 4086 patients overall
  6. d830 diabetic, 2840 non-diabetic, 3670 patients overall
  7. e244 diabetic, 760 non-diabetic, 1004 patients overall
  8. f910 diabetic, 3163 non-diabetic, 4073 patients overall
  9. g864 diabetic, 2985 non-diabetic, 3849 patients overall
  10. h909 diabetic, 3159 non-diabetic, 4068 patients overall
  11. i896 diabetic, 3146 non-diabetic, 4042 patients overall
  12. j894 diabetic, 3146 non-diabetic, 4040 patients overall 
  13. k894 diabetic, 3145 non-diabetic, 4039 patients overall
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Critical Care

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