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Table 1 Baseline characteristics of patients with AHRF (stratified by presence of diabetes)

From: Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

 

Overall (N = 4107)

Diabetic (N = 913)

Non-diabetic (N = 3194)

p value (Diabetic vs. non-diabetic)

Age (years)

61.7 ± 16.7

66.6 ± 13.1

60.3 ± 17.4

< 0.0001

Male – N (%)

2547 (62.0)

575 (63.0)

1972 (61.7)

0.50

BMI (kg/m2)a

27.5 ± 8.3

30.4 ± 11.7

26.6 ± 6.9

< 0.0001

Non-pulmonary SOFA score (adjusted for missing values)b

6.1 ± 4.1

6.2 ± 4.2

6.1 ± 4.0

0.39

ARDS risk factors – N (%)

   

0.07

 Pulmonary

2295 (55.9)

511 (52.0)

1784 (55.9)

 

 Non-pulmonary

833 (20.3)

174 (19.1)

659 (20.6)

 

 Pulmonary and non-pulmonary

559 (13.6)

115 (12.6)

444 (13.9)

 

 No risk factor

420 (10.2)

113 (12.4)

307 (9.6)

 

Co-morbidities – N (%)

    

 No co-morbidity other than diabetes mellitus

1958 (47.7)

343 (37.6)

1615 (50.6)

< 0.0001

 Chronic liver failure

161 (3.9)

33 (3.6)

128 (4.0)

0.37

 Chronic renal failure

428 (10.4)

205 (22.5)

227 (7.0)

< 0.0001

 Chronic cardiac failure (NYHA III-IV)

428 (10.4)

156 (17.1)

272 (8.5)

< 0.0001

 COPD or home ventilation

989 (24.1)

294 (32.2)

695 (21.8)

< 0.0001

 Active neoplasm

368 (9.0)

61 (6.7)

307 (9.6)

0.006

 Immunosuppression

453 (11.0)

73 (8.0)

380 (11.9)

0.0009

 Haematologic neoplasm

170 (4.1)

22 (2.4)

148 (4.6)

0.003

 Active neoplasm/immunosuppression/haematologic neoplasm

820 (20.0)

134 (14.7)

686 (21.5)

< 0.0001

Baseline ventilator variables

    

 PaO2:FiO2 ratio (mmHg)c

167.5 ± 67.8

169.2 ± 67.1

167.0 ± 68.0

0.35

 Tidal volume (ml/kg PBW)d

7.8 ± 2.2

8.0 ± 2.4

7.7 ± 2.1

0.05

 Plateau pressure (cmH2O)e

22.4 ± 5.9

23.3 ± 5.6

22.1 ± 6.0

0.001

 PEEP (cmH2O)f

7.8 ± 3.1

7.8 ± 3.1

7.8 ± 3.1

0.76

 Peak inspiratory pressure (cmH2O)g

24.8 ± 8.7

25.3 ± 8.8

24.7 ± 8.7

0.05

 Respiratory rate (breaths/min)h

21.2 ± 8.1

20.9 ± 6.7

21.3 ± 8.4

0.42

 Blood pHi

7.34 ± 0.12

7.33 ± 0.13

7.34 ± 0.12

0.06

 PaCO2 (mmHg)j

45.8 ± 15.6

46.0 ± 15.6

45.7 ± 15.6

0.51

 Bicarbonate (mmol/L)k

23.6 ± 6.8

23.4 ± 7.1

23.6 ± 6.7

0.36

  1. Data presented as mean ± standard deviation unless otherwise stated
  2. Abbreviations: AHRF acute hypoxaemic respiratory failure ARDS acute respiratory distress syndrome, BMI body mass index, COPD chronic obstructive pulmonary disease, NYHA New York heart association functional classification, PaCO2 partial pressure of carbon dioxide in arterial blood, PBW predicted body weight, PEEP positive end-expiratory pressure, SOFA sequential organ failure assessment
  3. a872 diabetic, 3010 non-diabetic, 3882 patients overall
  4. b908 diabetic, 3168 non-diabetic, 4076 patients overall
  5. c911 diabetic, 3175 non-diabetic, 4086 patients overall
  6. d830 diabetic, 2840 non-diabetic, 3670 patients overall
  7. e244 diabetic, 760 non-diabetic, 1004 patients overall
  8. f910 diabetic, 3163 non-diabetic, 4073 patients overall
  9. g864 diabetic, 2985 non-diabetic, 3849 patients overall
  10. h909 diabetic, 3159 non-diabetic, 4068 patients overall
  11. i896 diabetic, 3146 non-diabetic, 4042 patients overall
  12. j894 diabetic, 3146 non-diabetic, 4040 patients overall 
  13. k894 diabetic, 3145 non-diabetic, 4039 patients overall
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Critical Care

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