Table 2 Essential steps to reduce the burden of sepsis in low-resource settings
From: The global burden of sepsis: barriers and potential solutions
Strengthen public health and acute health care delivery systems  • Directly confront poverty and wealth inequalities  • Prevent the spread and acquisition of infectious diseases  • Accessible high-quality primary health care  • Functional public transportation and prehospital emergency medical services  • Strong, staffed, and well-supplied referral centers accessible to all  • Increased critical care capacity, both within and outside of ICUs | |
Accurately identify and quantify sepsis cases  • Nuanced operationalization of sepsis definitions  • Comprehensive, rigorous, population-level, sepsis-specific data collection in LMICs | |
Conduct inclusive research  • Increased partnership of adult and pediatric research communities  • Integrate sepsis research with disease-specific research and clinical communities  • Clinical trials in austere environments  • Implementation science research  • Open data access | |
Establish data-driven and context-specific management guidelines  • Partner with clinicians, public health professionals, and researchers to develop appropriate guidelines  • Validate recommendations in varied populations  • Focus on high-yield, cost-effective, and readily available interventions  • Balance disease-specific recommendations with general approaches | |
Promote creative interventions  • Timing and route of antimicrobials  • Diagnostics  • Organ support | |
Advocacy  • Support international sepsis initiatives  • Recognize sepsis as a major public health threat |