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Table 2 Essential steps to reduce the burden of sepsis in low-resource settings

From: The global burden of sepsis: barriers and potential solutions

Strengthen public health and acute health care delivery systems
 • Directly confront poverty and wealth inequalities
 • Prevent the spread and acquisition of infectious diseases
 • Accessible high-quality primary health care
 • Functional public transportation and prehospital emergency medical services
 • Strong, staffed, and well-supplied referral centers accessible to all
 • Increased critical care capacity, both within and outside of ICUs
Accurately identify and quantify sepsis cases
 • Nuanced operationalization of sepsis definitions
 • Comprehensive, rigorous, population-level, sepsis-specific data collection in LMICs
Conduct inclusive research
 • Increased partnership of adult and pediatric research communities
 • Integrate sepsis research with disease-specific research and clinical communities
 • Clinical trials in austere environments
 • Implementation science research
 • Open data access
Establish data-driven and context-specific management guidelines
 • Partner with clinicians, public health professionals, and researchers to develop appropriate guidelines
 • Validate recommendations in varied populations
 • Focus on high-yield, cost-effective, and readily available interventions
 • Balance disease-specific recommendations with general approaches
Promote creative interventions
 • Timing and route of antimicrobials
 • Diagnostics
 • Organ support
Advocacy
 • Support international sepsis initiatives
 • Recognize sepsis as a major public health threat
  1. ICU intensive care unit, LMIC low and middle-income country