Risk factors and outcomes for airway failure versus non-airway failure in the intensive care unit: a multicenter observational study of 1514 extubation procedures

Table 4 Main outcomes according to airway failure, non-airway failure and extubation success with corresponding crude odds ratios determined using multinomial logistic regression

Characteristic	Extubation success (n = 1311)	Airway failure (n = 65)				Non-airway failure (n = 77)				Airway vs non-airway failure
Characteristic	Extubation success (n = 1311)		OR	95% CI	P value		OR	95% CI	P value	P value
		–	–	–	–	–	–	–	–
Vasopressor use	97 (7)	16 (25)	4.087	2.240–7.454	< 0.0001	19 (25)	4.100	2.347–7.162	< 0.0001	0.99
Dialysis use	54 (4)	6 (9)	2.367	0.979–5.724	0.06	8 (10)	2.701	1.237–5.897	0.01	0.82
Hospital-acquired infections	120 (9)	22 (34)	5.078	2.939–8.775	< 0.0001	30 (39)	6.335	3.862–10.393	< 0.0001	0.53
Pneumonia	63 (5)	16 (25)	6.468	3.485–12.006	< 0.0001	26 (34)	10.099	5.910–17.258	< 0.0001	0.23
Catheter	23 (2)	3 (5)	2.713	0.794–9.275	0.11	3 (4)	2.270	0.666–7.734	0.19	1.00
Bloodstream	63 (5)	5 (8)	1.651	0.640–4.255	0.30	10 (13)	2.957	1.452–6.020	0.003	0.77
Urinary tract	29 (2)	5 (8)	3.684	1.377–9.853	0.009	5 (7)	3.070	1.154–8.166	0.02	1.00
Length of ICU stay	6.0 (2.0–13.0)	17.5 (11.0–30.0)	1.038	1.025–1.051	< 0.0001	16.5 (11.0–26.0)	1.025	1.012–1.039	0.0002	0.32
Length of hospital stay	17.0 (9.0–31.0)	28.5 (18.0–47.0)	1.011	1.005–1.017	0.0005	26.0 (13.0–41.0)	1.009	1.003–1.015	0.0021	0.28
Patient alive at ICU discharge	1237 (94)	52 (80)	0.239	0.125–0.459	< 0.0001	60 (78)	0.211	0.117–0.380	< 0.0001	0.76
Patient alive at hospital discharge	1182 (90)	48 (74)	0.308	0.172–0.552	< 0.0001	53 (69)	0.241	0.144–0.552	< 0.0001	0.51

Data are summarized as number of patients/total number of patients (%) or median (interquartile range). All P values and OR result from a univariate multinomial logistic regression predicting the two modalities of extubation failure (airway failure vs non-airway failure) according to the characteristics
OR odds ratio, CI confidence interval, ICU intensive care unit
*In the case of reintubation, several causes of reintubation could be provided for airway failure, non-airway failure or mixed airway and non-airway failures

ISSN: 1364-8535