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Table 1 Clinical characteristics and demographics of patients on ECMO

From: Extracorporeal membrane oxygenation offers long-term survival in childhood leukemia and acute respiratory failure

Clinical characteristics

N

Demographics

All

Survivors

Non-survivors

p-value

Diagnosis

 

Age (years)

14 (1–18)

9 (4–16)

16 (1–18)

0.286

 ALL

5

Weight (kg)

47 (7–74)

26 (12–50)

56 (7–74)

0.286

 AML

3

Pre ECMO

    

 JMML

1

pH

7.2 (7.0–7.6)

7.3 (7.0–7.6)

7.2 (7.0–7.4)

0.413

Reason for ARF

 

Lactate (mg/dL)

17 (7–68)

17 (7–24)

17 (8–68)

0.556

 Fungal infection

3

pO2/FiO2

47 (32–67)

66 (32–67)

44 (34–50)

0.286

 Pulmonary infectiona

4

VIS score

45 (5–160)

11 (5–45)

85 (22–160)

0.032

 TRALI

1

Platelet count (×  103/μL)

27 (14–214)

145 (26–214)

27 (14–53)

0.111

 Leukemic infiltration

1

Ventilation days

3 (0.4–14)

4.5 (1–13)

2 (0.4–12)

0.556

Causes of death on ECMO

 

During ECMO

    

 Intracranial hemorrhage

1

Platelet count (×  103/μL)

35 (19–106)

98 (22–106)

30 (19–48)

0.041

 Multiorgan failure

2

Platelets transfusions / day

2.2 (0.2–3.8)

0.5 (0.2–2.2)

3.3 (1.7–4.7)

0.111

 Leukemic infiltration

1

VV Cannulation

7

5

2

 

Outcome on ECMO

 

VA Cannulation

2

0

2

 

 Survived on ECMO

5

Major bleeding

4

0

4

 

 Discharged from hospital

4

Need for CRRT

3

0

3

 

 Survived long-term

4

ECMO Duration (days)

14 (2–24)

15 (9–24)

5 (2–17)

0.032

  1. ano organism detected
  2. ALL acute lymphoblastic leukemia, AML acute myeloid leukemia, JMML juvenile myelomonocytic leukemia, ARF acute respiratory failure, ano organism detected, ECMO extracorporeal membrane oxygenation, TRALI transfusion-related acute lung injury, VIS vasoactive inotrope score = dose of dopamine (μg/kg/min) + dose of dobutamine (μg/kg/min) + 100 x dose of adrenaline (μg/kg/min) + 100 x dose of noradrenaline (μg/kg/min) + 10 x milrinone dose (μg/kg/min) + 10,000 x dose of vasopressin (U/kg/min), VV veno-venous, VA veno-arterial, CRRT continuous renal replacement therapy