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Table 4 Clinical endpoints stratified by type of infection

From: Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials

 

Control group

PCT group

Adjusted OR or difference (95% CI)a, p value

p value for interaction

Subgroup by type of infection (suspected infection site)

 Respiratory

1101

1102

  

  Antibiotic therapy (days)

9.9 ± 7.8

8.5 ± 7.8

−1.36 (−1.99 to −0.73), p < 0.001

0.582

  30-day mortality

262 (23.8%)

243 (22.1%)

0.92 (0.79 to 1.07), p = 0.299

0.466

  Length of hospital stay (days)

28.2 ± 27.7

27.7 ± 24.7

−0.21 (−2.36 to 1.94), p = 0.849

0.668

  Length of ICU stay (days)

15.1 ± 16.6

15.3 ± 17.5

0.19 (−1.24 to 1.61), p = 0.798

0.858

 Urinary

129

118

  

  Antibiotic therapy (days)

12.5 ± 12.4

11.0 ± 12.2

−1.62 (−4.6 to 1.36), p = 0.286

0.786

  30-day mortality

21 (16.3%)

11 (9.3%)

0.59 (0.3 to 1.16), p = 0.128

0.215

  Length of hospital stay (days)

29.5 ± 25.4

25.1 ± 21.7

−4.08 (−9.7 to 1.54), p = 0.154

0.209

  Length of ICU stay (days)

14.3 ± 20.5

11.2 ± 13.6

−2.49 (−6.68 to 1.7), p = 0.244

0.123

 Abdominal

417

391

  

  Antibiotic therapy (days)

10.5 ± 10.6

11.0 ± 11.9

0.55 (−0.96 to 2.06), p = 0.477

0.005

  30-day mortality

109 (26.1%)

89 (22.8%)

0.87 (0.68 to 1.11), p = 0.266

0.821

  Length of hospital stay (days)

30.5 ± 27.7

32.1 ± 27.8

1.62 (−2.18 to 5.41), p = 0.404

0.361

  Length of ICU stay (days)

15.1 ± 15.3

15.7 ± 16.4

0.42 (−1.76 to 2.6), p = 0.704

0.634

 Skin/soft tissue

41

32

  

  Antibiotic therapy (days)

12.9 ± 15.8

8.6 ± 8.5

−4.57 (−10.36 to 1.23), p = 0.122

0.159

  30-day mortality

11 (27%)

8 (25%)

0.94 (0.43 to 2.06), p = 0.874

0.918

  Length of hospital stay (days)

26.0 ± 25.8

20.9 ± 23.4

−4.17 (−15.4 to 7.06), p = 0.467

0.442

  Length of ICU stay (days)

10.4 ± 9.4

10.9 ± 12.7

0.83 (−4.18 to 5.84), p = 0.747

0.916

 Central nervous system

35

38

  

  Antibiotic therapy (days)

11.7 ± 7.7

10.4 ± 7.7

−1.7 (−5.04 to 1.63), p = 0.317

0.958

  30-day mortality

3 (9%)

2 (5%)

0.61 (0.11 to 3.46), p = 0.58

0.692

  Length of hospital stay (days)

31.3 ± 22.8

30.8 ± 25.7

−0.44 (−11.48 to 10.6), p = 0.938

0.954

  Length of ICU stay (days)

10.8 ± 14.0

13.7 ± 13.1

2.91 (−3.22 to 9.04), p = 0.352

0.457

  1. Values are presented as mean ± standard deviation or n (%) as appropriate
  2. CI confidence interval, ICU intensive care unit, OR odds ratio, PCT procalcitonin
  3. aMultivariable hierarchical regression with outcome of interest as dependent variable and trial as a random effect