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Table 4 Clinical endpoints stratified by type of infection

From: Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials

  Control group PCT group Adjusted OR or difference (95% CI)a, p value p value for interaction
Subgroup by type of infection (suspected infection site)
 Respiratory 1101 1102   
  Antibiotic therapy (days) 9.9 ± 7.8 8.5 ± 7.8 −1.36 (−1.99 to −0.73), p < 0.001 0.582
  30-day mortality 262 (23.8%) 243 (22.1%) 0.92 (0.79 to 1.07), p = 0.299 0.466
  Length of hospital stay (days) 28.2 ± 27.7 27.7 ± 24.7 −0.21 (−2.36 to 1.94), p = 0.849 0.668
  Length of ICU stay (days) 15.1 ± 16.6 15.3 ± 17.5 0.19 (−1.24 to 1.61), p = 0.798 0.858
 Urinary 129 118   
  Antibiotic therapy (days) 12.5 ± 12.4 11.0 ± 12.2 −1.62 (−4.6 to 1.36), p = 0.286 0.786
  30-day mortality 21 (16.3%) 11 (9.3%) 0.59 (0.3 to 1.16), p = 0.128 0.215
  Length of hospital stay (days) 29.5 ± 25.4 25.1 ± 21.7 −4.08 (−9.7 to 1.54), p = 0.154 0.209
  Length of ICU stay (days) 14.3 ± 20.5 11.2 ± 13.6 −2.49 (−6.68 to 1.7), p = 0.244 0.123
 Abdominal 417 391   
  Antibiotic therapy (days) 10.5 ± 10.6 11.0 ± 11.9 0.55 (−0.96 to 2.06), p = 0.477 0.005
  30-day mortality 109 (26.1%) 89 (22.8%) 0.87 (0.68 to 1.11), p = 0.266 0.821
  Length of hospital stay (days) 30.5 ± 27.7 32.1 ± 27.8 1.62 (−2.18 to 5.41), p = 0.404 0.361
  Length of ICU stay (days) 15.1 ± 15.3 15.7 ± 16.4 0.42 (−1.76 to 2.6), p = 0.704 0.634
 Skin/soft tissue 41 32   
  Antibiotic therapy (days) 12.9 ± 15.8 8.6 ± 8.5 −4.57 (−10.36 to 1.23), p = 0.122 0.159
  30-day mortality 11 (27%) 8 (25%) 0.94 (0.43 to 2.06), p = 0.874 0.918
  Length of hospital stay (days) 26.0 ± 25.8 20.9 ± 23.4 −4.17 (−15.4 to 7.06), p = 0.467 0.442
  Length of ICU stay (days) 10.4 ± 9.4 10.9 ± 12.7 0.83 (−4.18 to 5.84), p = 0.747 0.916
 Central nervous system 35 38   
  Antibiotic therapy (days) 11.7 ± 7.7 10.4 ± 7.7 −1.7 (−5.04 to 1.63), p = 0.317 0.958
  30-day mortality 3 (9%) 2 (5%) 0.61 (0.11 to 3.46), p = 0.58 0.692
  Length of hospital stay (days) 31.3 ± 22.8 30.8 ± 25.7 −0.44 (−11.48 to 10.6), p = 0.938 0.954
  Length of ICU stay (days) 10.8 ± 14.0 13.7 ± 13.1 2.91 (−3.22 to 9.04), p = 0.352 0.457
  1. Values are presented as mean ± standard deviation or n (%) as appropriate
  2. CI confidence interval, ICU intensive care unit, OR odds ratio, PCT procalcitonin
  3. aMultivariable hierarchical regression with outcome of interest as dependent variable and trial as a random effect