Table 3 Clinical endpoints overall and stratified by sepsis severity and use of sepsis support
Control group | PCT group | Adjusted OR or difference (95% CI)a, p value | p value for interaction | |
|---|---|---|---|---|
2230 | 2252 | |||
Overall | ||||
Antibiotic therapy (days) | 10.4 ± 9.7 | 9.3 ± 9.2 | −1.19 (−1.73 to −0.66), p < 0.001 | |
30-day mortality | 529 (23.7%) | 475 (21.1%) | 0.89 (0.8 to 0.99), p = 0.03 | |
Length of hospital stay (days) | 28.7 ± 27.9 | 28.6 ± 27.9 | 0.09 (−1.51 to 1.7), p = 0.908 | |
Length of ICU stay (days) | 14.7 ± 16.3 | 14.8 ± 16.5 | 0.04 (−0.9 to 0.99), p = 0.928 | |
Subgroup by sepsis definition | ||||
Meeting sepsis 3 definition | 1630 | 1605 | ||
Antibiotic therapy (days) | 10.5 ± 9.2 | 9.3 ± 8.9 | −1.22 (−1.82 to −0.62), p < 0.001 | 0.915 |
30-day mortality | 397 (24.4%) | 338 (21.1%) | 0.86 (0.76 to 0.98), p = 0.022 | 0.388 |
Length of hospital stay (days) | 29.5 ± 27.9 | 29.6 ± 29.4 | 0.07 (−1.89 to 2.03), p = 0.946 | 0.891 |
Length of ICU stay (days) | 14.1 ± 15.5 | 14.5 ± 17.0 | 0.37 (−0.74 to 1.48), p = 0.51 | 0.246 |
Not meeting sepsis 3 definition | 600 | 647 | ||
Antibiotic therapy (days) | 10.2 ± 10.9 | 9.1 ± 9.9 | −1.13 (−2.27 to 0.01), p = 0.052 | 0.915 |
30-day mortality | 132 (22.0%) | 137 (21.2%) | 0.96 (0.78 to 1.19), p = 0.717 | 0.388 |
Length of hospital stay (days) | 26.4 ± 27.9 | 26.2 ± 23.7 | 0.16 (−2.53 to 2.84), p = 0.909 | 0.891 |
Length of ICU stay (days) | 16.5 ± 18.3 | 15.6 ± 15.2 | −0.82 (−2.65 to 1.01), p = 0.378 | 0.246 |
Subgroup by organ failure | ||||
SOFA 0 to 6 | 763 | 776 | ||
Antibiotic therapy (days) | 10.9 ± 10.3 | 8.1 ± 8.2 | −2.62 (−3.51 to −1.73), p < 0.001 | < 0.001 |
30-day mortality | 105 (13.8%) | 91 (11.7%) | 0.85 (0.66 to 1.1), p = 0.227 | 0.991 |
Length of hospital stay (days) | 28.6 ± 28.6 | 26.8 ± 25.8 | −1.96 (−4.65 to 0.72), p = 0.152 | 0.138 |
Length of ICU stay (days) | 12.9 ± 16.7 | 12.1 ± 15.6 | −0.92 (−2.52 to 0.69), p = 0.263 | 0.083 |
SOFA 7 to 9 | 474 | 445 | ||
Antibiotic therapy (days) | 10.1 ± 8.2 | 10.2 ± 9.4 | 0.01 (−1.1 to 1.11), p = 0.988 | 0.003 |
30-day mortality | 112 (23.6%) | 96 (21.6%) | 0.92 (0.73 to 1.17), p = 0.512 | 0.601 |
Length of hospital stay (days) | 30.7 ± 26.4 | 29.4 ± 25.9 | −1.14 (−4.52 to 2.24), p = 0.508 | 0.543 |
Length of ICU stay (days) | 14.0 ± 14.3 | 14.1 ± 15.3 | 0.23 (−1.66 to 2.12), p = 0.813 | 0.862 |
SOFA 10 to 24 | 486 | 486 | ||
Antibiotic therapy (days) | 10.7 ± 9.1 | 10.0 ± 8.8 | −0.63 (−1.71 to 0.45), p = 0.256 | 0.125 |
30-day mortality | 190 (39.1%) | 161 (33.1%) | 0.86 (0.72 to 1.01), p = 0.065 | 0.576 |
Length of hospital stay (days) | 29.4 ± 27.5 | 32.6 ± 35.5 | 3.21 (−0.76 to 7.18), p = 0.113 | 0.024 |
Length of ICU stay (days) | 15.6 ± 15.4 | 17.7 ± 19.2 | 2.08 (−0.08 to 4.24), p = 0.059 | 0.036 |
No septic shock (no vasopressor use) | 495 | 489 | ||
Antibiotic therapy (days) | 11.2 ± 9.9 | 9.8 ± 9.2 | −1.35 (−2.53 to −0.17), p = 0.025 | 0.586 |
30-day mortality | 79 (16.0%) | 76 (15.5%) | 0.97 (0.73 to 1.28), p = 0.823 | 0.512 |
Length of hospital stay (days) | 24.9 ± 26.3 | 23.2 ± 20.6 | −1.49 (−4.35 to 1.38), p = 0.309 | 0.258 |
Length of ICU stay (days) | 13.2 ± 15.6 | 12.7 ± 14.2 | −0.43 (−2.25 to 1.39), p = 0.642 | 0.47 |
Septic shock (with vasopressor use) | 1593 | 1606 | ||
Antibiotic therapy (days) | 10.4 ± 9.8 | 9.3 ± 9.4 | −1.03 (−1.68 to −0.39), p = 0.002 | 0.586 |
30-day mortality | 420 (26.4%) | 376 (23.4%) | 0.89 (0.79 to 1), p = 0.051 | 0.512 |
Length of hospital stay (days) | 30.1 ± 27.0 | 30.6 ± 26.3 | 0.6 (−1.23 to 2.43), p = 0.52 | 0.258 |
Length of ICU stay (days) | 15.0 ± 16.1 | 15.4 ± 17.0 | 0.34 (−0.8 to 1.49), p = 0.557 | 0.47 |
No respiratory failure (invasive ventilation support) | 672 | 651 | ||
Antibiotic therapy (days) | 11.0 ± 11.4 | 9.5 ± 9.6 | −1.43 (−2.49 to − 0.37), p = 0.008 | 0.467 |
30-day mortality | 104 (15.5%) | 83 (12.7%) | 0.83 (0.64 to 1.08), p = 0.158 | 0.633 |
Length of hospital stay (days) | 25.4 ± 21.7 | 25.3 ± 23.3 | −0.01 (−2.33 to 2.31), p = 0.993 | 0.788 |
Length of ICU stay (days) | 11.7 ± 13.5 | 12.4 ± 14.2 | 0.53 (− 0.86 to 1.92), p = 0.456 | 0.433 |
Respiratory failure (invasive ventilation support) | 1434 | 1478 | ||
Antibiotic therapy (days) | 10.2 ± 9.0 | 9.2 ± 9.2 | −1.09 (−1.73 to −0.45), p = 0.001 | 0.467 |
30-day mortality | 401 (28.0%) | 373 (25.2%) | 0.89 (0.79 to 1), p = 0.058 | 0.633 |
Length of hospital stay (days) | 30.9 ± 30.9 | 30.3 ± 26.0 | −0.39 (−2.42 to 1.65), p = 0.708 | 0.788 |
Length of ICU stay (days) | 16.2 ± 17.5 | 16.0 ± 17.5 | −0.3 (−1.56 to 0.95), p = 0.637 | 0.433 |
No renal replacement therapy | 1463 | 1495 | ||
Antibiotic therapy (days) | 9.4 ± 9.2 | 8.4 ± 8.6 | −1.02 (−1.64 to −0.39), p = 0.001 | 0.475 |
30-day mortality | 301 (20.6%) | 265 (17.7%) | 0.86 (0.74 to 1), p = 0.046 | 0.553 |
Length of hospital stay (days) | 29.8 ± 31.1 | 28.4 ± 25.5 | −1.41 (−3.4 to 0.59), p = 0.168 | 0.026 |
Length of ICU stay (days) | 14.6 ± 17.4 | 14.1 ± 15.9 | −0.64 (−1.82 to 0.53), p = 0.284 | 0.077 |
Renal replacement therapy | 767 | 757 | ||
Antibiotic therapy (days) | 12.3 ± 10.2 | 10.9 ± 10.0 | −1.45 (−2.44 to −0.46), p = 0.004 | 0.475 |
30-day mortality | 228 (29.7%) | 210 (27.7%) | 0.96 (0.83 to 1.11), p = 0.584 | 0.553 |
Length of hospital stay (days) | 26.6 ± 20.5 | 29.1 ± 32.2 | 2.97 (0.31 to 5.63), p = 0.028 | 0.026 |
Length of ICU stay (days) | 14.9 ± 14.0 | 16.2 ± 17.5 | 1.43 (−0.16 to 3.02), p = 0.079 | 0.077 |