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Table 1 Randomised controlled trials in progress

From: Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation

Title Country Summary Current status Registration number Links
AIRWAYS-2
randomised controlled trial of i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out of hospital cardiac arrest [36]
United Kingdom Cluster randomised trial comparing tracheal intubation with supraglottic airway (i-gel) insertion as the initial airway in out-of-hospital cardiac arrest.
Primary outcome: neurological outcome at hospital discharge or at 30 days if still hospitalised
Enrolment completed August 2017 ISRCTN08256118 https://www.ncbi.nlm.nih.gov/pubmed/27697605
Pragmatic Airway Resuscitation Trial (PART) [35] United States of America Cluster randomised trial comparing tracheal intubation and laryngeal tube insertion in out-of-hospital cardiac arrest.
Primary outcome: 72-h survival
Enrolment completed 2017 NCT02419573 https://www.ncbi.nlm.nih.gov/pubmed/26851059
Initial results presented and available at https://www.eventscribe.com/2018/SAEM/agenda.asp?h=Plenary&BCFO=PL (accessed 31 May 2018)
Reduction of oxygen after cardiac arrest: The EXACT trial Australia Phase 3 Randomised controlled trial comparing oxygen titrated to saturations of 90–94% with 98–100% as soon as possible after ROSC and continued until ICU admission.
Primary outcome: survival to hospital discharge.
Enrolment starts October 2017 NCT03138005 https://clinicaltrials.gov/ct2/show/record/NCT03138005?term=Reduction+of+oxygen+after+cardiac+arrest&rank=1
Targeted therapeutic mild hypercapnia after resuscitated cardiac arrest (TAME) Australia Randomised controlled trial comparing mild hypercapnia (PaCO2 50–55 mmHg) with targeted normocapnia (PaCO235–45 mmHg).
Primary outcome: neurological outcome at 6 months (GOSE)
Enrolment starts December 2017 NCT03114033 https://clinicaltrials.gov/ct2/show/NCT03114033
Targeting low- or high-normal Carbon dioxide, Oxygen, and Mean arterial pressure After Cardiac Arrest and REsuscitation: study protocol for a randomised pilot trial [74] Finland Feasibility study Enrolment complete NCT02698917 https://clinicaltrials.gov/ct2/show/NCT02698917