Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units

Table 4 Discrimination and reclassification of the combination of L-FABP and NT-proBNP for AKI

	C-index	P value	NRI	P value	IDI	P value
Established risk factor model	0.741	Ref.		Ref.		Ref.
Established risk factor model + NT-proBNP	0.762	0.38	0.316	<0.001	0.018	<0.001
Established risk factor model + L-FABP	0.794	0.03	0.561	<0.001	0.092	<0.001
Established risk factor model + NT-proBNP + L-FABP	0.803	0.01	0.606	<0.001	0.101	<0.001
Established risk factor model + NT-proBNP + L-FABP vs	0.041*	0.08	0.513	<0.001	0.083	<0.001
Established risk factor model + NT-proBNP	0.041*	0.08	0.513	<0.001	0.083	<0.001
Established risk factor model + NT-proBNP + L-FABP vs	0.009*	0.70	0.256	<0.001	0.009	0.006
Established risk factor model + L-FABP	0.009*	0.70	0.256	<0.001	0.009	0.006

Established risk factors included age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking status, chronic kidney disease, atrial fibrillation, acute decompensated heart failure, previous myocardial infarction, previous coronary revascularization, systolic blood pressure, heart rate, emergent coronary angiography or percutaneous coronary intervention before admission, mechanical ventilation before admission, intraaortic balloon pump before admission
L-FABP liver-type fatty acid-binding protein, NT-proBNP N-terminal pro-B-type natriuretic peptide, AKI acute kidney injury, NRI net reclassification improvement, IDI integrated discrimination improvement, Ref. reference
*Estimated differences between two groups

ISSN: 1364-8535