Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy

Table 5 Results of peak s-Tau nested cohort analysis for the employed multivariable models

Multivariable model	Estimate	95% CI	P value
Hypocapnia vs nonhypocapnia^a	1.07	0.73–1.57	0.71
Hypocapnia vs normocapnia^a	1.37	0.45–4.15	0.57
Hypercapnia vs nonhypercapnia^a	0.68	0.42–1.10	0.12
Hypercapnia vs normocapnia^a	1.00	0.38–2.64	1.00
Amplitude^b	1.04	0.91–1.20	0.53
AUC, all values^b	1.08	0.83–1.42	0.56
AUC, first four values^b	0.94	0.76–1.17	0.59
TTMH Mild hypercapnia vs normocapnia^a	0.75	0.43–1.28	0.29

s-Tau serum Tau, CI confidence interval, AUC area under curve, TTMH therapeutic targeted mild hypercapnia
^aFor analyses of categorical data, estimate indicates how many times higher s-Tau is compared to reference group
^bFor analyses of continuous data, estimate indicates how much higher s-Tau is per 1 kPa arterial carbon dioxide pressure increase

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