Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy

Table 3 Multivariate model of hypercapnia versus normocapnia in relation to neurological outcome

	OR	95% CI	P value
Hypercapnia (normocapnia reference)	0.70	0.44–1.11	0.13
TTM group (33 °C reference)	1.00	0.71–1.42	0.99
Age (per year)	1.07	1.05–1.08	< 0.001
Sex (male reference)	1.34	0.84–2.15	0.22
Chronic heart failure (yes/no)	2.09	0.98–4.46	0.06
Asthma/COPD (yes/no)	1.32	0.72–2.43	0.37
Bystander witnessed arrest (yes/no)	0.61	0.35–1.07	0.09
Bystander CPR (yes/no)	0.87	0.57–1.33	0.53
Time to ROSC (per min)	1.03	1.02–1.04	< 0.001
GCS-Motor score (1 vs 2–5)	2.5	1.72–3.57	< 0.001
Shock on admission (yes/no)	1.56	0.88–2.75	0.13
First rhythm shockable (yes/no)	0.19	0.11–0.33	< 0.001
pH (per 1.0 unit increase)	0.28	0.07–1.17	0.08

Hypercapnia = PaCO₂ > 6.0 kPa, normocapnia = PaCO₂ 4.5–6.0 kPa, hypocapnia = PaCO₂ < 4.5 kPa
OR < 1 indicates better outcome
OR odds ratio, CI confidence interval, TTM Target Temperature Management, COPD chronic obstructive pulmonary disease, CPR cardiopulmonary resuscitation, ROSC return of spontaneous circulation, GCS Glasgow Coma Scale

ISSN: 1364-8535