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Table 5 Bias assessment for primary outcomes of included observational studies

From: Platelet storage duration and its clinical and transfusion outcomes: a systematic review

Study Bias due to confounding Selection bias Bias due to classification of interventions Deviation from protocol Missing data Measurement of outcomes Selective reporting Overall risk of bias
Outcome: mortality
 Welsby et al. [23] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
 Inaba et al. [21] Moderate risk Low risk Low risk Low risk Unclear risk (no information) Low to moderate risk Moderate risk Moderate risk
 Flint et al. [22] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
Outcome: nosocomial infections
 Juffermans et al. [24] Moderate risk Low risk Low risk Low risk Unclear risk (no information) Low risk Moderate risk Moderate risk
 Juffermans et al. [25] Moderate risk Low risk Low risk Low risk Unclear risk (no information) Low risk Moderate risk Moderate risk
Outcome: bleeding
 Triulzi et al. [34] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
Outcome: CCI
 Kerkhoffs et al. [32] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
 Dijkstra-Tiekstra et al. [28] Serious risk Low risk Low risk Low risk Moderate risk Low risk Moderate risk Serious risk
 Van Rhenen et al. [35] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
 Heuft et al. [33] Serious risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk Serious risk
 Slichter et al. [12] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
 Akkok et al. [31] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
 Heim et al. [36] Moderate risk Low risk Low risk Low risk Unclear risk (no information) Low risk Moderate risk Moderate risk
 Dijkstra-Tiekstra et al. [29] Moderate risk Low risk Low risk Low risk Low risk Low risk Moderate risk Moderate risk
Outcome: PLT CI
 Kaplan et al., [30] Serious Low risk Low risk Low risk Unclear risk Low risk Moderate risk Serious risk
Outcome: TRAE
 Kaufman et al. [4] Moderate risk Low risk Low risk Low risk Low risk Low to moderate risk Moderate risk Moderate risk
  1. Abbreviations: CCI corrected count increment, PLT CI platelet count increment, TRAE transfusion-related adverse events