Table 1 Studies analysing the potential association between PLT storage duration and clinical or transfusion outcomes in critically ill patients
From: Platelet storage duration and its clinical and transfusion outcomes: a systematic review
Study | Population | Study design | PLT characteristics and maximum storage duration | Primary outcome | Secondary outcome | Analyses/comparator | Main results |
|---|---|---|---|---|---|---|---|
Welsby et al. [23] | Cardiac surgery, 2578 patients | Retrospective single centre | Leucoreduced Apheresis 5 days | 30-day mortality or hospital stay > 10 days | Infections Survival up to 5 years RBC requirement | All patients Patients with only one unit Oldest PLT transfused | No association |
Inaba et al. [21] | Trauma, 381 patients | Retrospective two-centre | Apheresis 5 days | Mortality | Sepsis ARDS AKI Liver failure ICU and hospital LOS RBC requirement | Patients with only PLTs stored for ≤ 3 days, 4 days and 5 days | No association with mortality More sepsis in the group transfused with PLTs stored for 5 days |
Juffermans et al. [24] | ICU, 134 patients | Retrospective single centre | Leucoreduced WBD, buffy coat derived a | Nosocomial infections | – | Number of PLTs > 4 days | No association |
Juffermans et al. [25] | Trauma, 196 patients | Retrospective single centre | Leucoreduced WBD, buffy coat derived a | Nosocomial infections | – | Number of PLTs > 4 days | No association |
Flint et al. [22] | ICU, 1430 patients | Retrospective two-centre | Leucoreduced Apheresis and WBD, buffy coat derived 5 days | Mortality | Blood stream infections and bacteriuria RBC requirement | All patients and patients receiving only one PLY unit Oldest PLTs, freshest PLTs and mean age of all PLTs | No association |