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Table 1 Studies analysing the potential association between PLT storage duration and clinical or transfusion outcomes in critically ill patients

From: Platelet storage duration and its clinical and transfusion outcomes: a systematic review

Study Population Study design PLT characteristics and maximum storage duration Primary outcome Secondary outcome Analyses/comparator Main results
Welsby et al. [23] Cardiac surgery, 2578 patients Retrospective single centre Leucoreduced
Apheresis
5 days
30-day mortality or hospital stay > 10 days Infections
Survival up to 5 years
RBC requirement
All patients
Patients with only one unit
Oldest PLT transfused
No association
Inaba et al. [21] Trauma, 381 patients Retrospective two-centre Apheresis
5 days
Mortality Sepsis
ARDS
AKI
Liver failure
ICU and hospital LOS
RBC requirement
Patients with only PLTs stored for ≤ 3 days, 4 days and 5 days No association with mortality
More sepsis in the group transfused with PLTs stored for 5 days
Juffermans et al. [24] ICU, 134 patients Retrospective single centre Leucoreduced WBD, buffy coat derived
a
Nosocomial infections Number of PLTs > 4 days No association
Juffermans et al. [25] Trauma, 196 patients Retrospective single centre Leucoreduced WBD, buffy coat derived
a
Nosocomial infections Number of PLTs > 4 days No association
Flint et al. [22] ICU, 1430 patients Retrospective two-centre Leucoreduced Apheresis and WBD, buffy coat derived
5 days
Mortality Blood stream infections and bacteriuria
RBC requirement
All patients and patients receiving only one PLY unit
Oldest PLTs, freshest PLTs and mean age of all PLTs
No association
  1. Abbreviations: ARDS acute respiratory distress syndrome, AKI acute kidney injury, PLT CCI platelet corrected count increment, ICU intensive care unit, LOS length of stay, WBD whole blood derived, PLT platelet, PLT CI platelet count increment
  2. aPLT storage duration not specified