Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns

Table 2 Outcomes of patients in high-volume haemofiltration and control groups

	Burn ≥ 50% TBSA			Burn ≥ 80% TBSA
	Control (n = 41)	HVHF (n = 41)	p Value	Control (n = 21)	HVHF (n = 17)	p Value
Mortality
28-day, n (%)	13 (31.7)	9 (22.0)	0.46	10 (47.6)	5 (29.4)	0.33
60-day, n (%)	17 (41.5)	11 (26.8)	0.24	13 (61.9)	5 (29.4)	0.06
90-day, n (%)	19 (46.3)	11 (26.8)	0.11	14 (66.7)	5 (29.4)^a	0.049
Sepsis, n (%)	21 (51.2)	11 (26.8)^a	0.04	15 (71.4)	6 (37.5)^a	0.04
Septic shock, n (%)	18 (43.9)	6 (14.6)^a	0.01	13 (61.9)	3 (18.6)^a	0.01
Duration of MV (days)	8.5 (5.3, 11.8)	7.0 (4.0, 10.5)	0.19	9.5 (2.5, 16.3)	7.0 (2.0, 8.0)	0.09
ICU days	28.5 (20.0, 48.0)	34.5 (15.5, 55.0)	0.84	31.0 (21.5, 47.5)	49.0 (18.0, 67.0)	0.23
Duration of vasopressors (days)	4.0 (2.0, 11.0)	1.0 (1.0, 1.0)^a	0.001	8.0 (2.0, 12.5)	1.5 (1.0, 2.8)^a	0.04

Abbreviations: TBSA Total burn surface area, MV Mechanical ventilation, ICU Intensive care unit, HVHF High-volume haemofiltration
Data are presented as medians (25th and 75th quantiles) or percentages. All patients were included in outcome comparisons via the intention-to-treat principle
^a p < 0.05 indicates a significant difference compared with the control group

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