Table 1 Baseline perioperative characteristics and outcome parameters
Variables | [TIMP-2•[IGFBP7] < 0.3 (n = 9) | [TIMP-2]•[IGFBP7] ≥ 0.3 (n = 9) | P value |
|---|---|---|---|
Age, yr, median (IQR) | 66.7 (58.3–71.6) | 73.4 (69.9–73.9) | 0.070 |
BMI, kg/m2, median (IQR) | 28.4 (24.8–31.0) | 28.1 (24.8–31.6) | 1.00 |
Sex, female | 2 | 3 | 0.624 |
Diabetes mellitus | 1 | 2 | 0.527 |
Smoking | 6 | 5 | 0.629 |
Coronary heart disease | 4 | 5 | 0.637 |
Hypertension | 8 | 8 | 1.000 |
SAPS II, median (IQR) | 27 (20.5–40.0) | 34 (27.0–53.5) | 0.112 |
SOFA score at admission, median (IQR) | 4.0 (1.0–8.0) | 8.0 (5.0–9.5) | 0.045 |
Ventilation days | 0.0 (0.0–1.05) | 0.75 (0.0–14.7) | 0.219 |
Preoperative IL-6, mg/dl, median (IQR) | 6.15 (5.22–20.95) | 6.8 (5.55–13.10) | 0.847 |
Preoperative hemoglobin, g/dl, median (IQR) | 12.8 (11.15–14.25) | 12.9 (11.05–13.75) | 0.965 |
Preoperative lactate, mg/dl, median (IQR) | 7.4 (6.00–8.50) | 8.0 (7.00–8.60) | 0.473 |
Preoperative ScvO2, %, median (IQR) | 82.0 (77.00–86.65) | 86.4 (84.35–87.85) | 0.077 |
Intraoperative values, median (IQR) | |||
Duration of surgery, min | 281.0 (203.5–347.0) | 422.0 (303.0–482.5) | 0.031 |
Intravenous contrast agent, ml | 240.0 (150.0–262.5) | 250.0 (179.25–337.0) | 0.469 |
Urine output, ml/h/kg | 1.6 (1.50–2.80) | 2.9 (1.70–4.75) | 0.132 |
Fluid balance, ml | 2420 (1850–3125) | 3350 (2915–4474) | 0.022 |
Blood transfusion, ml | 0.00 (0.00–0.00) | 600.0 (0.00–1500) | 0.014 |
Noradrenalin, mg | 0.85 (0.34–2.2) | 4.6 (1.65–6.67) | 0.012 |
MAP below 65 mmHg, % | 0.00 (0.00–7.00) | 0.00 (0.00–1.90) | 0.599 |
Postoperative values, median (IQR), at admission ICU | |||
Noradrenalin μg/kg/min | 0.06 (0.0–0.15) | 0.23 (0.07–0.30) | 0.046 |
Creatinine, mg/dl | 1.11 (0.95–1.39) | 0.87 (0.71–1.09) | 0.112 |
IL-6, mg/dl | 66.0 (43.25–276.45) | 406.9 (84.08–856.25) | 0.102 |
Hemoglobin, g/dl | 11.0 (9.3–13.35) | 10.2 (9.80–12.35) | 0.627 |
Lactate mg/dl | 9.8 (6.10–13.95) | 15.0 (9.5–18.60) | 0.170 |
ScvO2, %, | 76.2 (71.35–79.25) | 78.4 (68.3–81.80) | 0.427 |
Postoperative values, median (IQR), at 24 h | |||
Mean arterial pressure 0–24 h after admission | 76.1 (72.4–87.7) | 75.7 (68.5–84.7) | 0.310 |
Doppler RI both kidneys at 24 h | 0.73 (0.67–0.76) | 0.73 (0.72–0.80) | 0.232 |
IL-6, mg/dl, at 24 h | 167.8 (31.75–221.00) | 185.1 (36.20–633.25) | 0.354 |
Hemoglobin, g/dl, at 24 h | 10.1 (8.35–12.5) | 9.6 (8.4–11.05) | 0.930 |
Lactate, mg/dl, at 24 h | 11.4 (6.55–14.95) | 14.0 (10.00–31.00) | 0.122 |
ScvO2, %, at 24 h | 68.9 (65.4–74.65) | 76.2 (68.05–81.25) | 0.200 |
Furosemide dose 0–24 h, mg | 10.0 (0.0. 25.0) | 30.0 (5.0–45.0) | 0.133 |
Outcome parameters | |||
AKI | 2 | 7 | 0.02 |
AKI Stage 2 and 3 | 0 | 3 | 0.058 |
RRT | 0 | 2 | 0.134 |
In-hospital mortality | 0 | 2 | 0.134 |