Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study

Table 3 Multivariate analysis of risk factors for hospital mortality

Factors	OR	95% CI	P
Interventional cohort	1.08	0.89–1.31	0.419
Age^a	1.02	1.01–1.03	< 0.001
Sex^b	0.82	0.67–1.01	0.057
SOFA^a	1.11	1.07–1.15	< 0.001
APACHE II^a	1.08	1.06–1.10	< 0.001
Charlson^a	1.06	1.02–1.11	0.005
Type of infection^c
Nosocomial	2.03	1.61–2.56	< 0.001
ICU	2.49	1.61–3.87	< 0.001
Healthcare-related	1.33	0.99–1.79	0.058
Source of sepsis^d
Acute abdominal infection	0.79	0.63–1.00	0.051
Urinary tract infection	0.25	0.18–0.35	< 0.001
Meningitis	1.11	0.60–2.05	0.742
Soft-tissue infection	0.69	0.47–1.03	0.072
Catheter-related bacteremia	0.54	0.27–1.09	0.084
Other infections	1.00	0.66–1.52	0.999

Abbreviations: SOFA Sequential Organ Failure Assessment, APACHE II Acute Physiology and Chronic Health Evaluation II, ICU intensive care unit
^aPer each point of increase
^bCompared with male sex
^cCompared to community-acquired infection.
^dCompared to pneumonia

ISSN: 1364-8535