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Table 2 Clinical endpoints in immunocompetent (Control) and immunocompromised (Study) patients

From: Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database

Clinical endpoints Control
(n = 2229)
Study
(n = 584)
p Value
IMV during ICU stay, n (%) 1874 (84.1) 462 (79.1) 0.0044
NIV success during ICU stay, n (%) 212 (9.5) 63 (10.8) 0.3551
NIV failure during ICU stay, n (%) 143 (6.4) 59 (10.1) 0.0021
Duration of mechanical ventilation, d, median (Q1–Q3) 8.0 (4.0–15.0) 8.0 (4.0–14.0) 0.4213
Progression/regression of ARDSa, n (%)    0.5613
 No change 824 (41.7) 201 (39.6)  
 Progression 214 (10.8) 55 (10.8)  
 Regression 422 (21.3) 123 (24.2)  
 Resolution 518 (26.2) 129 (25.4)  
Limitation of life-sustaining measures, n (%)    
 Decision to withhold life-sustaining measures 415 (18.6) 158 (27.1) < 0.0001
 Decision to withdraw life-sustaining measures 356 (16.0) 129 (22.1) 0.0005
 Decision to withhold or withdraw life-sustaining measures 507 (22.7) 195 (33.4) < 0.0001
ICU mortalityb, n (%) 698 (31.3) 266 (45.5) < 0.0001
Hospital mortalityc, n (%)    
 All patients 804 (36.2) 304 (52.4) < 0.0001
 Patients with limitations of life-sustaining measuresd 419 (82.6) 173 (88.7) 0.0473
  1. Abbreviations: ARDS Acute respiratory distress syndrome, IMV Invasive mechanical ventilation, ICU Intensive care unit, NIV Noninvasive mechanical ventilation, Q 1 First quartile, Q 3 Third quartile
  2. aChange in ARDS severity (according Berlin definition) was not evaluable for 327 pients (251 immunocompetent and 76 immunocompromised patients)
  3. bMortality is defined as mortality at ICU discharge or at the 90th day in the ICU after onset of acute hypoxemic respiratory failure, whichever event occurred first
  4. cMortality is defined as mortality at hospital discharge or at the 90th day in the hospital after onset of acute hypoxemic respiratory failure, whichever event occurred first
  5. dMortality assessed on patients with a decision to withhold or withdraw life-sustaining measures
  6. Note: Bold p values represent a statistically significant difference between the two groups