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Table 2 Clinical endpoints in immunocompetent (Control) and immunocompromised (Study) patients

From: Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database

Clinical endpoints

Control

(n = 2229)

Study

(n = 584)

p Value

IMV during ICU stay, n (%)

1874 (84.1)

462 (79.1)

0.0044

NIV success during ICU stay, n (%)

212 (9.5)

63 (10.8)

0.3551

NIV failure during ICU stay, n (%)

143 (6.4)

59 (10.1)

0.0021

Duration of mechanical ventilation, d, median (Q1–Q3)

8.0 (4.0–15.0)

8.0 (4.0–14.0)

0.4213

Progression/regression of ARDSa, n (%)

  

0.5613

 No change

824 (41.7)

201 (39.6)

 

 Progression

214 (10.8)

55 (10.8)

 

 Regression

422 (21.3)

123 (24.2)

 

 Resolution

518 (26.2)

129 (25.4)

 

Limitation of life-sustaining measures, n (%)

   

 Decision to withhold life-sustaining measures

415 (18.6)

158 (27.1)

< 0.0001

 Decision to withdraw life-sustaining measures

356 (16.0)

129 (22.1)

0.0005

 Decision to withhold or withdraw life-sustaining measures

507 (22.7)

195 (33.4)

< 0.0001

ICU mortalityb, n (%)

698 (31.3)

266 (45.5)

< 0.0001

Hospital mortalityc, n (%)

   

 All patients

804 (36.2)

304 (52.4)

< 0.0001

 Patients with limitations of life-sustaining measuresd

419 (82.6)

173 (88.7)

0.0473

  1. Abbreviations: ARDS Acute respiratory distress syndrome, IMV Invasive mechanical ventilation, ICU Intensive care unit, NIV Noninvasive mechanical ventilation, Q 1 First quartile, Q 3 Third quartile
  2. aChange in ARDS severity (according Berlin definition) was not evaluable for 327 pients (251 immunocompetent and 76 immunocompromised patients)
  3. bMortality is defined as mortality at ICU discharge or at the 90th day in the ICU after onset of acute hypoxemic respiratory failure, whichever event occurred first
  4. cMortality is defined as mortality at hospital discharge or at the 90th day in the hospital after onset of acute hypoxemic respiratory failure, whichever event occurred first
  5. dMortality assessed on patients with a decision to withhold or withdraw life-sustaining measures
  6. Note: Bold p values represent a statistically significant difference between the two groups
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Critical Care

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