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Table 1 Patients characteristics in immunocompetent (Control) and immunocompromised (Study) groups

From: Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database

Patients characteristics Control
(n = 2229)
Study
(n = 584)
p Value
Sex, age, and BMI
 Women, n (%) 837 (37.6) 247 (42.3) 0.0360
 Age, yr, mean ± SD 61.6 ± 17.1 60.3 ± 15.5 0.0163
 BMI (kg/m2), mean ± SD 28.1 ± 9.2 25.5 ± 5.8 < 0.0001
Comorbidities, n (%)
 COPD 522 (23.4) 85 (14.6) < 0.0001
 Diabetes mellitus 523 (23.5) 90 (15.4) < 0.0001
 Hearth failure (NYHA classes III-IV) 260 (11.7) 30 (5.1) < 0.0001
 Chronic renal failure 222 (10.0) 64 (11.0) 0.4769
 Chronic liver failure (Child-Pugh class C) 91 (4.1) 21 (3.6) 0.5924
 Home ventilation 52 (2.3) 7 (1.2) 0.0886
ARDS risk factors, n (%)
 Pneumonia 1271 (57.0) 412 (70.5) < 0.0001
 Pulmonary contusion 86 (3.9) 1 (0.2) < 0.0001
 Pulmonary vasculitis 7 (0.3) 7 (1.2) 0.0140
 Major trauma 111 (5.0) 1 (0.2) < 0.0001
 Aspiration of gastric contents 348 (15.6) 54 (9.2) < 0.0001
 Pancreatitis 54 (2.4) 5 (0.9) 0.0187
 Noncardiogenic shock 154 (6.9) 60 (10.3) 0.0063
 Drug overdose 46 (2.1) 5 (0.9) 0.0515
 Severe burns 8 (0.4) 0 (0.0) 0.2183
 Inhalational injury 58 (2.6) 12 (2.1) 0.4498
 Drowning 1 (0.04) 1 (0.2) 0.3722
 Nonpulmonary sepsis 361 (16.2) 94 (16.1) 0.9535
 Blood transfusions 82 (3.7) 29 (5.0) 0.1550
 Other risk factors 61 (2.7) 12 (2.2) 0.4925
 None 194 (8.7) 40 (6.8) 0.1487
Cause of immunosuppression, n (%)
 Known (hematologic and/or active neoplasm) 357 (61.1)
 Unknown 227 (38.9)
Illness severity at ARDS onset
 Nonpulmonary SOFA scorea, mean ± SD
  First day of ARDS 6.2 ± 4.1 6.5 ± 4.0 0.1150
  Second day of ARDS 6.3 ± 4.3 6.7 ± 4.3 0.0283
 PaO2/FiO2 ratio, mmHg, mean ± SD 161.3 ± 67.1 157.2 ± 67.9 0.1660
 Mild ARDSb, n (%) 666 (29.9) 167 (28.6) 0.5455
 Moderate ARDSb, n (%) 1067 (47.9) 271 (46.4) 0.5280
 Severe ARDSb, n (%) 496 (22.3) 146 (25.0) 0.1590
  1. Abbreviations: BMI Body mass index, ARDS Acute respiratory distress syndrome, COPD Chronic obstructive pulmonary disease, NYHA New York Heart Association, SOFA Sequential Organ Failure Assessment, PaO 2 /FiO 2 Ratio of partial pressure of arterial oxygen to fraction of inspired oxygen
  2. Note: Bold p values represent a statistically significant difference between the two groups
  3. aNonpulmonary SOFA score adjusted for missing values
  4. bSeverity of ARDS was evaluated according to the Berlin definition