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Table 8 Factors impacting drug removal by renal replacement therapies

From: Antiepileptic drugs in critically ill patients

Drug-related factors

RRT-related factors

• Low protein binding

• Mode of dialysis (CRRT vs. IHD vs. others)

• Low volume of distribution

• RRT filter membrane (sieving coefficient)

• Predominantly renally eliminated

• Dialysis prescription (mode and flow rates)

• Low molecular weight

• Duration/frequency of renal replacement

  1. CRRT continuous renal replacement therapy, IHD intermittent hemodialysis, RRT renal replacement therapy
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Critical Care

ISSN: 1364-8535