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Table 4 AED-AED drug interactions [113116]

From: Antiepileptic drugs in critically ill patients

  CBZ CNP DZP LAC LAM MDZ OXZ PEN PMP PHB PHT PFL TOP
ZON ↓ZON    ↓LAC    ↓ZON ↓ZON   ↓ZON ↓ZON   ↓ZON
↑CBZ
VPA ↓VPA ? risk of absence seizures    ↑ LAM   ↓OXZ   ↑VPA ↑PHB ↑PHT ↑PFL ↓VPA
↑CBZ ↓VPA ↓VPA
TOP ↓VPA   ↑ DZP    ↓MDZ   ↓TOP ↓ PMP ↓TOP ↑PHT   
↓TOP ↓TOP
PHT ↓↑CBZ   ↓ DZP ↓LAC ↓ LAM ↓MDZ   ↓PEN ↓ PMP ↓PHT    
↓↑PHT
PHB ↓CBZ   ↓ DZP   ↓ LAM ↓MDZ ↓OXZ       
PEN ↓CBZ   ↓ DZP    ↓MDZ        
OXZ ↓CBZ   ↑↓DZP    ↓MDZ        
↓OXZ
MDZ ↓MDZ             
LAM ↓LAM             
LAC ↓LAC             
DZP ↓DZP             
↑CBZ
CNP              
BRV ↓BRV             
  1. ↑ and ↓ indicate increased and decreased levels and/or effects, respectively
  2. AED antiepileptic drug, CBZ carbamazepine, CNP clonazepam, GBT gabapentine, GTC generalized tonic-clonic, LAC lacosamide, LAM lamotrigine, LEV levetiracetam, OXZ oxcarbazepine, PMP perampanel, PHB phenobarbital, PHT phenytoin, PGB pregabalin, TOP topiramate, VPA valproic acid, ZON zonisamide