Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials

Table 1 Characteristics of included studies

Study	N	Age			Strategy of blood transfusion				Units of RBC transfusion or transfusion rate
		Restrictive	Control	Setting	Restrictive		Control		Restrictive	Control
		Restrictive	Control	Setting	Triggered Hb	Observed Hb	Triggered Hb	Observed Hb	Restrictive	Control
Bracey et al.1999 [12]	428	61 ± 11	62 ± 11	Elective CABG	Hb < 8 g/dl	9.1 g/dl	Hb < 9 g/dl	9.7 g/dl	0.9 ± 1.5	1.4 ± 1.8
Murphy et al. 2007 [16]	321	NS	NS	Elective or urgent cardiac surgery	Hb < 7 g/dl	NS	Hb < 8 g/dl	NS	NS	NS
Hajjar et al. 2010 [13]	502	58.6 ± 12.5	60.7 ± 12.5	Elective cardiac surgery	Hct < 24%	9.6 g/dl	Hct < 30%	10.7 g/dl	0 (0–2)	2 (1–3)
Shehata et al. 2012 [15]	50	67.2 ± 11.2	68.8 ± 9.2	Cardiac surgery with CARE score of 3 or 4	Hb < 7.5 g/dl	9.1 g/dl	Hb < 10 g/dl	10.7 g/dl	11 (44)	17 (68)
Murphy et al. 2015 [14]	2003	69.9(63.1 –76.0)	70.8(64.1–76.7)	Elective or urgent cardiac surgery	Hb < 7.5 g/dl	9.0 g/dl	Hb < 9 g/dl	9.8 g/dl	1 (0–2)	2 (1–3)
Koch et al. 2017 [10]	717	59 ± 15	60 ± 13	Elective CABG or HVR	Hct < 24%	28%	Hct < 28%	30%	195 (54)	265 (75)
Mazer et al. 2017 [9]	4860	72 ± 10	72 ± 10	Cardiac surgery with a EuroSCORE I of 6 or more	Hb < 7.5 g/dl	Hb < 8.5 g/dl	Hb < 9.5 g/dl	10.5 g/dl?	2 (1–4)	3 (2–5)

CABG coronary artery bypass grafting, Hb hemoglobin, Hct hemotocrit, HVR heart valve replacement, NS normal saline

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