Table 2 Summary of randomized controlled trials comparing routine use of mechanical CPR with manual CPR in IHCA
| Â | Load-distributing band trials | Piston-device trials | |
|---|---|---|---|
| Â | Halperin et al. [44] | Taylor et al. [43] | Lu et al. [42]a |
Design | Efficacy superiortity single-centre RCT | Efficacy superiortity single-centre RCT | Efficacy superiority single-centre RCT |
Randomisation | Patient (ratio 1:1) | Patient (ratio 1:1) | Patient (ratio 1:1) |
Inclusion criteria | IHCA of less than 20-min duration following tracheal intubation and adrenaline administration | IHCA of less than 10-min duration | IHCA of less than 10-min duration |
Number of cases analysed | 34 | 50 | 150 |
Setting | US | US | China |
Sponsor | Academicb | Academic | Unclear |
Device used | Load-distributing band device | Thumper device | Thumper device |
Primary outcome | ROSC Manual 18% vs mechanical 47%, OR 4.15 (95% CI 0.86, 19.92) | One-hour survival Manual 38% vs mechanical 42%, OR 1.14 (95% CI 0.37, 3.55) | STD Manual 15% vs mechanical 33%, OR 2.81 (95% CI 1.26, 6.24) |
Key secondary outcomes | 24-h survival: Manual 6% vs mechanical 18% | STD: Manual 8% vs mechanical 13%, OR 1.71 (95% CI 0.26, 11.26) | ROSC: Manual 38% vs mechanical 55%, OR 2.03 (95% CI 1.06, 3.90) |