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Table 2 Summary of randomized controlled trials comparing routine use of mechanical CPR with manual CPR in IHCA

From: Mechanical CPR: Who? When? How?

  Load-distributing band trials Piston-device trials
  Halperin et al. [44] Taylor et al. [43] Lu et al. [42]a
Design Efficacy superiortity single-centre RCT Efficacy superiortity single-centre RCT Efficacy superiority single-centre RCT
Randomisation Patient (ratio 1:1) Patient (ratio 1:1) Patient (ratio 1:1)
Inclusion criteria IHCA of less than 20-min duration following tracheal intubation and adrenaline administration IHCA of less than 10-min duration IHCA of less than 10-min duration
Number of cases analysed 34 50 150
Setting US US China
Sponsor Academicb Academic Unclear
Device used Load-distributing band device Thumper device Thumper device
Primary outcome ROSC
Manual 18% vs mechanical 47%, OR 4.15 (95% CI 0.86, 19.92)
One-hour survival
Manual 38% vs mechanical 42%, OR 1.14 (95% CI 0.37, 3.55)
Manual 15% vs mechanical 33%, OR 2.81 (95% CI 1.26, 6.24)
Key secondary outcomes 24-h survival: Manual 6% vs mechanical 18% STD: Manual 8% vs mechanical 13%, OR 1.71 (95% CI 0.26, 11.26) ROSC: Manual 38% vs mechanical 55%, OR 2.03 (95% CI 1.06, 3.90)
  1. aPublished only in Chinese
  2. bNine authors report equity interest in company holding device patent
  3. IHCA in-hospital cardiac arrest, RCT randomised controlled trial, STD survival to discharge