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Table 5 Colonization in surveillance samples by colistin- and tobramycin-resistant pathogens

From: Long-term use of selective digestive decontamination in an ICU highly endemic for bacterial resistance

Variables SDD period (between October 2011 and September 2015)
Total 1st year 2nd year 3rd year 4th year
(n = 285) (n = 59) (n = 56) (n = 69) (n = 101)
Male sex, % 66.7 67.8 71.4 60.9 67.2
Age, years, mean ± SD 60.7 ± 15.0 56.2 ± 14.4 61.0 ± 16.0 61.3 ± 12.4 62.4 ± 16.1
Total patients 3948 1067 1069 851 961
Patients with SDD 1998 522 381 430 665
Colistin
 Resistance at ICU admission 113 (39.6) 5 (8.5) 17 (30.4) 30 (43.5) 61 (60.4)
 Development of resistance 30 (10.5) 3 (5.1) 8 (14.3) 7 (10.1) 12 (11.9)
Observed (at ICU admission)
 Rate/100 patients 2.86 0.47 1.59 3.53 6.35
 Rate/100 patients SDD 5.66 0.96 4.46 6.98 9.17
Estimated (acquired in ICU)
 Rate/100 patients 0.76 0.28 0.75 0.82 1.25
 Rate/100 patients SDD 1.5 0.57 2.1 1.63 1.8
Tobramycin
 Resistance at ICU admission 151 (52.9) 17 (6.0) 32 (11.2) 34 (11.9) 68 (23.9)
 Development of resistance 30 (10.5) 1 (0.4) 3 (1.1) 15 (5.3) 11 (3.9)
Observed (at ICU admission)
 Rate/100 patients 3.82 1.59 2.99 3.99 7.08
 Rate/100 patients SDD 7.56 3.26 8.4 7.91 10.23
Estimated (acquired in ICU)     
 Rate/100 patients 0.76 0.09 0.28 1.76 1.14
 Rate/100 patients SDD 1.5 0.19 0.79 3.49 1.65
  1. ICU Intensive care unit, SDD Selective digestive tract decontamination
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