Table 1 Results of univariate analysis
Variables | Non-SDD cohort (n = 110) | SDD cohort (n = 258) | P value |
|---|---|---|---|
Male sex | 74 (67.3) | 166 (64.3) | 0.589 |
Age, years, mean ± SD | 59.5 ± 15.8 | 60.7 ± 16.4 | 0.539 |
APACHE II score on admission, mean ± SD | 21.2 ± 7.7 | 22.0 ± 7.7 | 0.345 |
Glasgow Coma Scale score, median (IQR) | 15 (8–15) | 14.5 (8–15) | 0.098 |
Diagnosis on ICU admission | 0.289 | ||
Medical | 79 (71.8) | 190 (73.6) | |
Scheduled surgery | 10 (9.1) | 33 (12.8) | |
Emergency surgery | 21 (19.1) | 35 (13.6) | |
Septic response | 0.399 | ||
Sepsis | 57 (52.8) | 110 (45.45) | |
Septic shock | 51 (47.2) | 132 (54.55) | |
Prior surgery | 18 (16.4) | 37 (14.3) | 0.618 |
Urgent surgery | 34 (30.9) | 70 (27.1) | 0.461 |
Trauma patients | 17 (15.5) | 31 (12.0) | 0.370 |
Current smokers | 21 (19.1) | 31 (27.4) | 0.141 |
Underlying illness | |||
Diabetes mellitus | 34 (30.9) | 86 (33.3) | 0.650 |
Coronary artery disease | 19 (17.3) | 45 (17.4) | 0.969 |
Chronic liver disease | 6 (5.5) | 18 (7.0) | 0.588 |
Chronic obstructive lung disease | 9 (8.2) | 43 (16.7) | 0.032 |
Solid neoplasm | 10 (9.1) | 26 (10.1) | 0.771 |
Chronic renal failure | 40 (36.4) | 56 (21.7) | 0.003 |
Renal replacement therapy | 34 (30.9) | 91 (35.3) | 0.419 |
Parenteral nutrition | 26 (23.6) | 50 (19.4) | 0.356 |
Immunosuppression | 8 (7.3) | 22 (8.5) | 0.687 |
Malnutrition | 12 (10.9) | 24 (9.3) | 0.635 |
ICU-acquired infection | |||
VAP | 59 (53.6) | 102 (39.5) | 0.013 |
CLABSI | 26 (23.6) | 106 (41.1) | 0.001 |
Secondary BSI | 31 (28.2) | 47 (18.2) | 0.023 |
Urinary tract infection | 29 (26.4) | 73 (28.3) | 0.705 |
Infections caused by MDRB | |||
Gram-negative bacilli | 12 (10.9) | 8 (3.1) | 0.002 |
Acinetobacter spp. | 13 (11.8) | 3 (1.2) | < 0.001 |
ESBL-producing MDRB | 38 (34.5) | 62 (24.0) | 0.038 |
Pseudomonas aeruginosa | 10 (9.1) | 23 (8.9) | 0.957 |
Methicillin-resistant Staphylococcus aureus | 4 (3.6) | 5 (1.9) | 0.460 |
ICU stay, days, median (IQR) | 28 (16–45) | 33 (17–50) | 0.192 |
ICU mortality | 36 (32.7) | 85 (33.2) | 0.929 |