Table 3 Cross-sectional analysis of biomarkers one day prior to clinical occurrence of delirium; data are expressed as median (IQR)
From: Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study
No delirium (n = 15) | Delirium (n = 35) | Hypoactive delirium (n = 11) | Mixed delirium (n = 23) | Hyperactive delirium (n = 1) | |
|---|---|---|---|---|---|
Inflammation | |||||
TNF a (pg/mL) | 4 (4–16) | 4 (4–16) | 4 (4–16) | 4 (4–16) | 4 |
IL-6 (pg/mL) | 343 (39–1171) | 212 (75–412) | 234 (195–461) | 109 (51–365) | 981 |
IL-1 beta (pg/mL) | 4 (4–6) | 4 (4–8) | 4 (4–8) | 4 (4–8) | 8 |
IL-10 (pg/mL) | 19 (8–28) | 12 (5–28) | 28 (12–39)a | 9 (4–12) | 20 |
Neopterin (mmol/L) | 51 (19–111) | 36 (23–95) | 111 (37–111)b | 29 (16–64) | 24 |
MCP-1 (pg/mL) | 143 (56–620) | 239 (117–547) | 454 (141–596) | 168 (90–350) | 953 |
Adinopectin (ng/mL) | 6065 (3163–8466) | 7997 (4421–12,880) | 7391 (3952–10,499) | 7997 (5014–16,099) | 8212 |
Brain | |||||
Aβ1–42 (pg/mL) | 54 (46–86) | 57 (46–70) | 63 (45–81) | 55 (46–67) | 70 |
Aβ1–40 (pg/mL) | 174 (135–227) | 200 (152–272) | 229 (200–274) | 167 (142–247) | 194 |
Ratio Aβ1–40/42 | 0.34 (0.25–0.4) | 0.26 (0.23–0.35) | 0.26 (0.19–0.31) | 0.27 (0.23–0.38) | 0.36 |
Tau-protein (pg/mL) | 31.25 (31.25–52) | 31.25 (31.25–101) | 90 (46–224)c | 31.25 (31.25–75) | 31.25 |
Ratio tau/Aβ1–42 | 0.68 (0.54–0.96) | 0.91 (0.51–1.48) | 1.42 (0.9–2.57)d | 0.66 (0.5–1.36) | 0.45 |