Skip to main content

Table 2 Median levels (interquartile range) of biomarkers over time; p-values indicate the between-subject differences between delirium and non-delirium groups

From: Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study

 

Delirium (n = 35)

Non-delirium (n = 15)

 

Day 1

Day 2

Day 4

Day 6

Day 1

Day 2

Day 4

Day 6

p value

Inflammation

 TNF a (pg/mL)

10 (4–16)

4 (4–16)

4.0 (4–16)

4.0 (4–16)

4.0 (4–16)

4.0 (4–16)

4.0 (4–16)

4.0 (4–16)

0.24

 IL-6 (pg/mL)

250 (82–1300)

163 (51–365)

75 (33–130)

43 (26–77)

343 (39–1171)

52 (20–446)

23 (16–102)

14 (11–39)

0.29

 IL-1 beta (pg/mL)

4 (4–8)

4 (4–8)

4 (4–8)

4 (4–8)

4 (4–8)

4 (4–4)

4 (4–5)

4 (4–4)

0.13

 IL-10 (pg/mL)

12 (7–25)

12 (4–24)

9 (5–18)

7 (4–14)

21 (8–36)

11 (5–21)

8 (4–18)

7 (5–33)

0.82

 Neopterin (mmol/L)

37 (18–91)

50 (19–99)

45 (21–111)

39 (22–101)

51 (19–111)

76 (23–111)

62 (28–111)

74 (28–111)

0.18

 MCP-1 (pg/mL)

233 (141–642)

239 (97–630)

171 (101–369)

120 (74–263)

143 (56–645)

141 (67–575)

82 (26–180)

70 (33–95)

0.08

 Adiponectin (ng/mL)

7821 (4421–13,910)

8986 (4775–12,880)

9737 (6169–15,416)

10,379 (6486–20,695)

6065 (3163–8466)

4927 (4345–8023)

6232 (4393–9457)

6404 (4880–11,550)

0.05

Brain

 Aβ1–42 (pg/mL)

58 (46–77)

56 (42–79)

53 (41–64)

55 (38–68)

54 (46–86)

56 (44–88)

54 (39–79)

54 (43–62)

0.74

 Aβ1–40 (pg/mL)

179 (164–247)

181 (155–280)

177 (146–243)

177 (146–246)

165 (135–232)

169 (125–212)

156 (125–238)

181 (128–257)

0.61

 Ratio Aβ1–40/42

0.28 (0.24–0.36)

0.28 (0.23–0.32)

0.28 (0.23–0.35)

0.26 (0.22–0.36)

0.34 (0.25–0.38)

0.33 (0.27–0.46)

0.30 (0.27–0.43)

0.29 (0.25–0.34)

0.37

 Tau-protein (pg/mL)

31.25 (31.25–59)

31.25 (31.25–120)

31.25 (31.25–101)

31.25 (31.25–87)

31.25 (31.25–52)

31.25 (31.25–69)

36 (31.25–63)

49 (31.25–73)

0.19

 Ratio Tau/ Aβ1–42

0.68 (0.50–1.19)

0.83 (0.56–1.43)

0.90 (0.59–1.70)

0.89 (0.74–1.29)

0.68 (0.59–0.96)

0.71 (0.53–1.03)

0.80 (0.58–1.42)

0.88 (0.65–1.36)

0.20