From: Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study
Delirium (n = 35) | Non-delirium (n = 15) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Day 1 | Day 2 | Day 4 | Day 6 | Day 1 | Day 2 | Day 4 | Day 6 | p value | |
Inflammation | |||||||||
TNF a (pg/mL) | 10 (4–16) | 4 (4–16) | 4.0 (4–16) | 4.0 (4–16) | 4.0 (4–16) | 4.0 (4–16) | 4.0 (4–16) | 4.0 (4–16) | 0.24 |
IL-6 (pg/mL) | 250 (82–1300) | 163 (51–365) | 75 (33–130) | 43 (26–77) | 343 (39–1171) | 52 (20–446) | 23 (16–102) | 14 (11–39) | 0.29 |
IL-1 beta (pg/mL) | 4 (4–8) | 4 (4–8) | 4 (4–8) | 4 (4–8) | 4 (4–8) | 4 (4–4) | 4 (4–5) | 4 (4–4) | 0.13 |
IL-10 (pg/mL) | 12 (7–25) | 12 (4–24) | 9 (5–18) | 7 (4–14) | 21 (8–36) | 11 (5–21) | 8 (4–18) | 7 (5–33) | 0.82 |
Neopterin (mmol/L) | 37 (18–91) | 50 (19–99) | 45 (21–111) | 39 (22–101) | 51 (19–111) | 76 (23–111) | 62 (28–111) | 74 (28–111) | 0.18 |
MCP-1 (pg/mL) | 233 (141–642) | 239 (97–630) | 171 (101–369) | 120 (74–263) | 143 (56–645) | 141 (67–575) | 82 (26–180) | 70 (33–95) | 0.08 |
Adiponectin (ng/mL) | 7821 (4421–13,910) | 8986 (4775–12,880) | 9737 (6169–15,416) | 10,379 (6486–20,695) | 6065 (3163–8466) | 4927 (4345–8023) | 6232 (4393–9457) | 6404 (4880–11,550) | 0.05 |
Brain | |||||||||
Aβ1–42 (pg/mL) | 58 (46–77) | 56 (42–79) | 53 (41–64) | 55 (38–68) | 54 (46–86) | 56 (44–88) | 54 (39–79) | 54 (43–62) | 0.74 |
Aβ1–40 (pg/mL) | 179 (164–247) | 181 (155–280) | 177 (146–243) | 177 (146–246) | 165 (135–232) | 169 (125–212) | 156 (125–238) | 181 (128–257) | 0.61 |
Ratio Aβ1–40/42 | 0.28 (0.24–0.36) | 0.28 (0.23–0.32) | 0.28 (0.23–0.35) | 0.26 (0.22–0.36) | 0.34 (0.25–0.38) | 0.33 (0.27–0.46) | 0.30 (0.27–0.43) | 0.29 (0.25–0.34) | 0.37 |
Tau-protein (pg/mL) | 31.25 (31.25–59) | 31.25 (31.25–120) | 31.25 (31.25–101) | 31.25 (31.25–87) | 31.25 (31.25–52) | 31.25 (31.25–69) | 36 (31.25–63) | 49 (31.25–73) | 0.19 |
Ratio Tau/ Aβ1–42 | 0.68 (0.50–1.19) | 0.83 (0.56–1.43) | 0.90 (0.59–1.70) | 0.89 (0.74–1.29) | 0.68 (0.59–0.96) | 0.71 (0.53–1.03) | 0.80 (0.58–1.42) | 0.88 (0.65–1.36) | 0.20 |