Skip to main content

Table 3 Predictors of disability in survivors of community-acquired sepsis

From: Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)

 

No disability at discharge (n = 385)

Disability at discharge (n = 173)

Univariable odds ratio for disability (95% CI)

P

Multivariable odds ratio for disability (95% CI)

P

Sex

 Male

196/385 (51%)

90/173 (52%)

Reference

   

 Female

189/385 (49%)

83/173 (48%)

1.0 (0.7–1.4)

0.81

NA

Age

 29 days–12 months (infants)

145/385 (38%)

38/173 (22%)

Reference

   

 1–5 years (toddlers)

135/385 (35%)

70/173 (41%)

2.0 (1.3–3.1)

< 0.01

1.8 (0.8–4.1)

0.14

 5–12 years (school-aged children)

55/385 (14%)

39/173 (23%)

2.7 (1.6–4.7)

< 0.001

2.6 (1.0–7.0)

0.05

 12–18 years (adolescents)

50/385 (13%)

26/173 (15%)

2.0 (1.1–3.6)

0.02

2.0 (0.7–6.0)

0.20

Time interval from onset of symptoms to hospital admissiona (days)

1 (1–3)

1 (1–3)

1.0 (0.9–1.0)

0.16

0.9 (0.9–1.0)

0.07

Immunizations up to date

 No

29/334 (9%)

17/157 (11%)

Reference

   

 Yes

305/334 (91%)

140/157 (89%)

0.8 (0.4–1.5)

0.45

NA

Underlying condition

 No

266/385 (69%)

83/173 (48%)

Reference

   

 Yes

119/385 (31%)

90/173 (52%)

2.4 (1.7–3.5)

< 0.001

1.9 (0.9–3.6)

0.08

Illness severity

 PRISM score

12 (6–19)

16 (11–23)

1.1 (1.0–1.1)

< 0.001

NA

 

 PIM2 scoreb (predicted death, %)

3.1 (0.9–7.1)

6.8 (2.3–17.2)

2.7 (1.9–3.9)

< 0.001

3.4 (1.8–6.4)

< 0.001

 Lactate at PICU admissionc (mmol/L)

1.6 (1.0–3.2)

2.3 (1.2–4.5)

2.0 (1.0–3.8)

0.04

NA

 

 Invasive ventilation

242/370 (65%)

139/167 (83%)

2.6 (1.7–4.2)

< 0.001

NA

 Inotropes

196/365 (54%)

112/166 (68%)

1.8 (1.2–2.6)

< 0.01

NA

Bacteremia

 No

262/385 (68%)

112/173 (65%)

Reference

   

 Yes

123/385 (32%)

61/173 (35%)

1.2 (0.8–1.7)

0.44

NA

Clinical syndromes

 No focus

146/385 (38%)

48/173 (28%)

0.6 (0.4–0.9)

0.02

0.9 (0.3–2.4)

0.83

 Meningitis/encephalitis

74/385 (19%)

49/173 (28%)

1.7 (1.1–2.5)

0.02

1.0 (0.3–3.2)

0.95

 Pneumonia

57/385 (15%)

49/173 (28%)

2.3 (1.5–3.5)

< 0.001

1.2 (0.4–3.8)

0.73

 Other focus

108/385 (28%)

27/173 (16%)

0.5 (0.3–0.8)

< 0.01

1.0 (0.3–3.0)

0.96

Invasive pathogens

 N. meningitidis

81/177 (45%)

18/87 (21%)

0.3 (0.2–0.6)

< 0.001

0.5 (0.2–1.3)

0.16

 S. pneumoniae

12/177 (7%)

27/87 (31%)

6.3 (3.0–13.2)

< 0.001

5.4 (1.8–15.8)

< 0.01

 Group A streptococcus

31/177 (18%)

15/87 (17%)

1.0 (0.5–2.0)

1.0

NA

 

 S. aureus

16/177 (9%)

11/87 (13%)

1.5 (0.7–3.4)

0.34

NA

 Other invasive pathogen

37/177 (21%)

16/87 (18%)

0.9 (0.4–1.6)

0.63

NA

  1. This study included 795 children with community-acquired sepsis, of whom 173 patients were discharged with disability, i.e. Pediatric Overall Performance Category score 2– 5 [29], need of skin graft, hearing loss, or need of amputation (51 deaths and 186 patients with missing data are not included in this analysis). Multivariable analysis included variables with a P value < 0.20 in univariable analysis. Because parameters of illness severity are strongly correlated, only the Pediatric Index of Mortality 2 (PIM2) score [28] has been included in multivariable analysis. Values are reported as counts (percentages) or medians (interquartile ranges), unless stated otherwise
  2. PRISM Pediatric Risk of Mortality [27], NA not applicable
  3. aTime interval from onset of symptoms to hospital admission was available for 372/385 patients without disability and for 154/173 patients with disability at discharge
  4. bData were log transformed for univariable and multivariable analysis
  5. cData on lactate at pediatric ICU admission were available for 247/385 patients without disability and for 109/173 patients with disability at discharge. Data were log transformed for univariable analysis
Back to article page

Critical Care

ISSN: 1364-8535