| Sepsis survivors (n = 744) | Deaths (n = 51) | Univariable odds ratio for death (95% CI) | P | Multivariable odds ratio for death (95% CI) | P |
---|---|---|---|---|---|---|
Sex | ||||||
 Male | 399/744 (54%) | 29/51 (57%) | Reference |  |  |  |
 Female | 345/744 (46%) | 22/51 (43%) | 0.9 (0.5–1.6) | 0.65 | NA | |
Age | ||||||
 29 days–12 months (infants) | 248/744 (33%) | 13/51 (26%) | Reference |  |  |  |
 1–5 years (toddlers) | 259/744 (35%) | 19/51 (37%) | 1.4 (0.7–2.9) | 0.37 | NA | |
 5–12 years (school -aged children) | 140/744 (19%) | 11/51 (22%) | 1.5 (0.7–3.4) | 0.34 | NA | |
 12–18 years (adolescents) | 97/744 (13%) | 8/51 (16%) | 1.6 (0.6–3.9) | 0.33 | NA | |
Time interval from onset of symptoms to hospital admissiona (days) | 1 (1–3) | 2 (1–4) | 1.0 (1.0–1.1) | 0.47 | NA |  |
Immunizations up to date | ||||||
 No | 70/621 (11%) | 2/36 (6%) | Reference |  |  |  |
 Yes | 551/621 (89%) | 34/36 (94%) | 2.2 (0.5–9.2) | 0.30 | NA | |
Underlying condition | ||||||
 No | 479/744 (64%) | 28/51 (55%) | Reference |  |  |  |
 Yes | 265/744 (36%) | 23/51 (45%) | 1.5 (0.8–2.6) | 0.18 | 0.7 (0.2–2.0) | 0.46 |
Illness severity | ||||||
 PRISM scoreb | 14 (7–20) | 22 (15–30) | 1.1 (1.0–1.1) | < 0.001 | NA |  |
 PIM2 scorec (predicted death, %) | 3.9 (1.0–9.1) | 14.7 (3.8–48.0) | 3.9 (2.1–7.2) | < 0.001 | 2.8 (1.3–6.1) | < 0.01 |
 Lactate at PICU admissiond (mmol/L) | 1.7 (1.0–3.3) | 3.3 (2.3–5.4) | 8.9 (2.7–29.1) | < 0.001 | NA |  |
 Invasive ventilation | 474/705 (67%) | 45/47 (96%) | 11.0 (2.6–45.6) | 0.001 | NA | |
 Inotropes | 377/693 (54%) | 41/46 (89%) | 6.9 (2.7–17.6) | < 0.001 | NA | |
Bacteremia | ||||||
 No | 445/741 (60%) | 13/51 (26%) | Reference |  |  |  |
 Yes | 296/741 (40%) | 38/51 (75%) | 4.4 (2.3–8.4) | < 0.001 | 7.4 (1.0–56.6) | 0.06 |
Clinical syndromes | ||||||
 No focus | 254/744 (34%) | 24/51 (47%) | 1.7 (1.0–3.0) | 0.06 | 3.0 (0.8–10.9) | 0.09 |
 Meningitis/encephalitis | 172/744 (23%) | 10/51 (20%) | 0.8 (0.4–1.6) | 0.56 | NA |  |
 Pneumonia | 138/744 (19%) | 11/51 (22%) | 1.2 (0.6–2.4) | 0.59 | NA | |
 Other focus | 180/744 (24%) | 6/51 (12%) | 0.4 (0.2–1.0) | 0.05 | 1.8 (0.3–11.8) | 0.52 |
Invasive pathogense | ||||||
 N. meningitidis | 120/386 (31%) | 11/39 (28%) | 0.8 (0.4–1.8) | 0.88 | NA |  |
 S. pneumoniae | 65/386 (17%) | 13/39 (33%) | 2.5 (1.2–5.1) | 0.01 | 4.1 (1.1–16.0) | 0.04 |
 Group A streptococcus | 60/386 (16%) | 6/39 (15%) | 1.0 (0.4–2.5) | 1.0 | NA |  |
 S. aureus | 37/386 (10%) | 4/39 (10%) | 1.1 (0.4–3.2) | 0.88 | NA |  |
 Other invasive pathogen | 104/386 (27%) | 5/39 (13%) | 0.4 (0.2–1.0) | 0.06 | 0.3 (0.0–2.2) | 0.21 |