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Table 6 Linear regression model for all cases

From: Influence of pathogen and focus of infection on procalcitonin values in sepsis patients with bacteremia or candidemia

Variable

Regressioncoefficient

95% CI

p value

Multiplier

(95% CI)

Staphylococcus spp.

0.13

(0.06–0.2)

< 0.001

1.4 (1.2–1.6)

Streptococcus spp.

0.59

(0.47–0.71)

< 0.001

3.9 (3.0–5.1)

Enterococcus spp

0.17

(0.03–0.29)

0.01

1.5 (1.1–2.0)

Escherichia coli

0.62

(0.54–0.7)

< 0.001

4.2 (3.5–5.)

Enterobacteriaceae, other

0.56

(0.46–0.65)

< 0.001

3.7 (2.9–4.6)

Pseudomonas spp.

0.23

(− 0.02 to 0.47)

0.07

1.7 (1.0–2.9)

Candida spp.

0.07

(− 0.11 to 0.24)

0.44

1.2 (0.8–1.8)

Several pathogens

0.46

(0.36–0.56)

< 0.001

2.9 (2.3–3.7)

Rare pathogens

0.28

(0.16–0.4)

< 0.001

1.9 (1.5–2.6)

No pathogen detected

Reference

  

Reference

Respiratory

−0.24

(− 0.32 to – 0.16)

< 0.001

0.6 (0.5–0.7)

Abdominal

0.14

(0.06–0.22)

< 0.001

1.5 (1.3–1.8)

Urogenital

0.18

(0.08–0.27)

< 0.001

1.6 (1.3–2.0)

Bones/soft tissue

− 0.17

(− 0.27 to – 0.07)

< 0.001

0.8 (0.6–1.0)

Several foci

−0.13

(− 0.22 to – 0.04)

< 0.001

0.8 (0.7–1.0)

Other/unknown

Reference

  

Reference

Intercept

0.70

(0.62–0.77)

< 0.001

4.5 (3.9–5.3)

  1. Stepwise linear regression for influence of pathogens in blood culture and focus of infection on logPCT (p < 0.001 for both steps) including all 4857 cases with PCT measurement and blood cultures taken; adjusted R2 = 0.15; effect of the interaction term not significant (p = 0.47) and it was omitted from the final model
  2. After reversal of the logarithmic transformation, the multiplier equals 10regression coefficient, resulting in PCTpredicted = 4.5 × pathogen × focus × error
  3. CI confidence interval, PCT procalcitonin