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Table 2 Suggested chronobiological approaches to preserve circadian rhythms on the intensive care unit (ICU)

From: Clinical chronobiology: a timely consideration in critical care medicine

Zeitgeber

Ideal ICU environment

Light

• Bright-light daylight hours (> 1000 lx)

• Minimise light pollution at night (< 1 lx, consider)

• Eye masks at night

Feeding

• Intermittent daytime feeding aligned to usual meal times

• Avoid continuous and overnight feeding

Temperature

• Warmer environment during the day and cooler at night

Exercise rehabilitation

• Similar time each day

• Take patient chronotype into consideration when planning schedule

Noise

• Minimise noise during the night time

• Ear plugs at night

Medical and nursing interventions

• Minimise at night and cohort together

• For non-sedated patients, allow patients to sleep according to their natural schedule, rather than a staff-based schedule

Sedative drugs

• Minimise use through regular review and avoid “sleeping tablets”

• Consider melatonin (up to 5 mg) at 0900 h as circadian preserving sleep aide

• When possible, give drugs at the time of day least disturbing to circadian rhythms