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Table 1 Consequences of ‘wrong thing–wrong time’ leading to circadian desynchronisation in critically ill patients

From: Clinical chronobiology: a timely consideration in critical care medicine

Circadian misalignment Clinical outcome
Sleep–wake inversion Sleep loss [113]
Delirium [114]
Poor compliance with physiotherapy and rehabilitation [115]
Continuous feeding at night time Glucose intolerance [64]
Dyslipidaemia [72]
Metabolic dysfunction [71]
Invasive interventions at night time Impaired wound healing [101]