Female, n (%)

6 (32)

Age, mean (SD)

65.3 (9.7)

Body mass index (kg/m^{2}), median (25–75th percentile)

29.7 (22.5–32.7)

SAPS II at ICU admission, mean (SD)

57.5 (24)

Main diagnosis

Pneumonia, n (%)

4 (21)

Sepsis, n (%)

1 (5)

COPD/asthma exacerbation, n (%)

1 (5)

Cardiac failure, n (%)

3 (16)

Drug overdose/acute mental status change, n (%)

5 (26)

Intraabdominal sepsis with surgery, n (%)

5 (26)

Comorbidity

Chronic pulmonary disease, n (%)

6 (32)

Obesity, n (%)

9 (47)

Chronic cardiac insufficiency, n (%)

5 (26)

Cancer, n (%)

1 (5)

Chronic kidney disease, n (%)

3 (16)

Diabetes mellitus, n (%)

7 (37)

Between admission and inclusion

Septic shock, n (%)

6 (31)

ARDS, n (%)

5 (26)

Renal failure, n (%)

8 (42)

Use of cathecolamines, n (%)

13 (68)

Use of neuromuscular blockers, n (%)

10 (53)

No. of days of neuromuscular blockers, median (25–75th percentile)

1 (0–2)

Ventilator use (days), median (25–75th percentile)

4 (2–7)

Ventilator parameters and sedation use during protocol

Pressure support (cmH_{2}O), mean (SD)

15 (3)

Positive endexpiratory pressure (cmH_{2}O), mean (SD)

7 (1)

Fraction of inspired oxygen (%), mean (SD)

35 (13)

Midazolam mg/h, mean (SD)

5 (4)
