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Table 3 Association between volume of intravenous fluids administered and the change in haemoglobin (Hb) concentration

From: Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Change in Hb over 24 h Univariate analysis
−1.0 (−1.4 to −0.6) Hb g/L per litre of fluid administered
R2 = 2.5%, P < 0.001
  Multivariate Analysis *
− 1.0 (− 1.5 to − 0.6) Hb g/L per litre of fluid administered
R2 = 9.3%, P < 0.001
Change in Hb over 72 h Univariate analysis
− 1.5 (− 1.8 to − 1.2) Hb g/L per litre of fluid administered
R2 = 8.9%, P < 0.001
  Multivariate Analysis #
− 1.3 (− 1.6 to − 0.9) Hb g/L per litre of fluid administered
R2 = 17.7%, P < 0.001
  1. *Significant covariates were weight, APACHE-II, lactate, receiving vasoactive agents at baseline and study group. Complete data was available for 776 patients
  2. #Significant covariates were age and serum lactate. Complete data was available for 594 patients