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Table 1 Cohort characteristics at enrolment

From: Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Characteristic Cohort (N = 1275)
Age – years (IQR) 65 (51–75)
Male – N (%) 782 (61.3%)
Weight – kg (IQR) 77 (65–90)
Charlson Comorbidity Index – score (IQR) 1 (0–2)
APACHE-IIa – score (IQR) 14 (10–19)
Receiving mechanical ventilation – N (%)
 Invasive 105 (8.2%)
 Non-invasive 84 (6.6%)
Systolic pressure – mmHg (IQR) 95 (85–110)
Receiving a vasoactive agent infusionbN (%) 187 (14.7%)
Intravenous fluids administered prior to enrolmentc
 Volume – L (IQR) 2.5 (1.7–3.3)
 Volume per weight – mL/kg (IQR) 31.8 (19.4–45.2)
Serum lactate – mmol/L (IQR) 3.9 (2.1–5.2)
Serum creatinine – μmol/L (IQR) 128 (93–195)
Randomisation groupdN (%)
 Early goal directed therapy 614 (48.2%)
 Usual care 661 (51.8%)
Source of sepsis – N (%)
 Blood 110 (8.6%)
 Lung 452 (35.5%)
 Abdomen 98 (7.7%)
 Urinary 261 (20.5%)
 Central nervous system 16 (1.3%)
 Soft tissue 127 (10.0%)
 Other 98 (7.7%)
 Unknown 113 (8.9%)
  1. aAcute Physiology and Chronic Health Evaluation-II (APACHE-II) score was calculated from data at randomisation into the ARISE study group
  2. bInfusion of vasoactive agents included noradrenaline, adrenaline, metaraminol, phenylephrine and/or dopamine for at least 30 min prior to enrolment
  3. cTotal intravenous fluid volume prior to enrolment included those given by ambulance personnel and in hospital
  4. dThere were 796 patients randomised to early goal-directed therapy (EGDT) and 804 to usual care in the ARISE study. Exclusion criteria for this cohort study applied to 182 from the EGDT study group and 143 from the usual care group