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Table 1 Pulmonary gas exchange, serum lactate and airway pressures

From: High-frequency oscillatory ventilation guided by transpulmonary pressure in acute respiratory syndrome: an experimental study in pigs

  T0 PEEP 5 ARDS PEEP 5 ARDS PEEP 10 ARDS PEEP 20
pHa Median 25% 75% Median 25% 75% Median 25% 75% Median 25% 75%
 VCV 7.47 7.46 7.50 7.36 7.35 7.39 7.34^ 7.32 7.42 7.31 7.28 7.34
 ARDS HFOV con 7.54 7.49 7.58 7.51 7.47 7.52
 ARDS HFOV PL mean 7.46 7.36 7.52 7.58 7.51 7.59
PaCO2, mmHg
 VCV 41.5 38.3 42.8 45.0# 43.0 46.5 50.5^ 46.3 52.0 51.0© 48.3 55.3
 ARDS HFOV con 28.0 27.0 30.3 29.5 27.0 33.3
 ARDS HFOV PL mean 40.5 32.8 47.5 28.0 25 29.3
PaO2, mmHg
 VCV 666.0* 647.8 675.8 71.0 65.3 80.8 54.0 50.8 71.8 88.0 46.0 121.8
 ARDS HFOV con 51.0 39.8 71.8 67.5 39.0 105.8
 ARDS HFOV PL mean 43.5 40.5 52.8 63.0 53.0 131.1
Lactate, mmol/l
 VCV 1.9* 1.5 2.4 2.4 1.6 3.1 2.4 2.0 2.8 2.8 2.4 3.3
 ARDS HFOV con 2.7 2.5 3.2 2.6 2.5 3.0
 ARDS HFOV PL mean 2.6 2.1 3.0 2.8 2.6 3.4
Airway pressures
 Plateau airway pressure VCV 14.5 14.0 16.0 24.5 23.8 26.0 29.5 28.0 30.3 38.5 37.8 39.0
Mean air pressure
 VCV 8.0 8.0 8.7 11.5 11.3 12.0 16.5 16.0 16.8 26.1 25.9 26.3
 HFOV con 20.5 19.5 21.0 30.0 30.0 30.0
 HFOV PL mean 11.0 11.0 16.3 20.5 17.0 22.8
Mean esophageal pressure
 VCV 4.5 1.2 8.4 4.5 3.7 9.2 10.0 7.1 12.3 12.2 10.2 14.3
 HFOV con 10.0 7.1 12.3 11.5 9.3 14.3
 HFOV PL mean 8.5 7.0 9.3 9.0 7.0 11.5
PL mean
 VCV 3.8 0.0 6.8 6.7 3.4 7.3 6.3 4.1 9.7 13.5 11.9 15.5
 HFOV con 9.5 6.5 13.3 18.5 15.8 20.8
 HFOV PL mean 3.0 1.5 9.0 11.5 7.8 15.8
  1. Values are medians (25th and 75th quartiles) in eight animals
  2. T 0 PEEP 5 start of the experiment without acute respiratory distress syndrome (ARDS) and positive end-expiratory pressure (PEEP = 5 cmH2O), ARDS PEEP 5/10/20 ARDS with PEEP of 5, 10, and 20 cm H2O, VCV conventional volume controlled ventilation, HFOV high frequency oscillatory ventilation, HFOV con conventional high frequency oscillatory ventilation, HFOV P L mean HFOV guided by mean transpulmonary pressure, pHa pH in arterial blood, PaCO 2 arterial carbon dioxide tension, PaO 2 arterial oxygen tension, Paw mean airway pressure, P L transpulmonary pressure (PL = Paw-esophageal pressure)
  3. *p < 0.05 VCV T0 PEEP 5 vs. VCV ARDS PEEP 5; ^p < 0.05 VCV ARDS PEEP 10 vs. HFOV con “PEEP 10”; p < 0.05 VCV ARDS PEEP 10 vs. HFOV PL mean “PEEP 10”; p < 0.05 HFOV con ARDS “PEEP 10” vs. HFOV PL mean ARDS “PEEP 10”; ©p < 0.05 VCV ARDS PEEP 20 vs. HFOV con “PEEP 20”; £p < 0.05 VCV ARDS PEEP 20 vs. HFOV PL mean “PEEP 20”; Ωp < 0.05 HFOV con ARDS “PEEP 20” vs. HFOV PL mean ARDS “PEEP 20”; p < 0.05 (p values were determined using the Wilcoxon test for paired samples)