Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality

Table 4 Associations between cellular markers and death during first 90 days after Staphylococcus aureus bacteremia

	Associations between each variable and death during first 90 days after infection			Multivariable model
	HR	95% CI	p Value	HR	95% CI	p Value
Th17 at day 3	1.03	0.98–1.08	0.25	NS	NS	NS
Th1 at day 3	0.99	0.90–1.09	0.79	NS	NS	NS
Th2 at day 3	0.89	0.83–0.96	< 0.01	0.86	0.78–0.94	< 0.01
Treg at day 3	1.06	0.98–1.15	0.17	1.13	1.00–1.28	0.046
Th17/Treg at day 3	0.92	0.81–1.05	0.22	NS	NS	NS
Th1/Treg at day 3	0.70	0.45–1.09	0.11	NS	NS	NS
Th2/Treg at day 3	0.74	0.57–0.98	0.03	NS	NS	NS
ΔTh17/day	1.62	1.08–2.44	0.02	NS	NS	NS
ΔTh1/day	0.56	0.29–1.09	0.09	NS	NS	NS
ΔTh2/day	0.93	0.60–1.43	0.73	NS	NS	NS
ΔTreg/day	0.76	0.45–1.29	0.32	NS	NS	NS
Δ(Th17/Treg)/day	3.60	1.53–8.49	< 0.01	4.41	1.69–11.5	< 0.01
Δ(Th1/Treg)/day	7.0	0.17–283	0.30	NS	NS	NS
Δ(Th2/Treg)/day	3.0	0.51–17.2	0.22	NS	NS	NS

Th T-helper cell, Treg Regulatory T cell
Cellular markers measured early after infection and over the course of the infection were predictor variables. The association between each cellular marker and death was determined using a Cox proportional hazards model. A multivariable Cox proportional hazards model was used to determine the adjusted associations between cellular markers and death. Nonsignificant (NS) variables (p > 0.05) were removed from the multivariable model using backward selection

ISSN: 1364-8535