Parameters | Early RRT (n = 58) | Standard RRT (n = 60) | P value |
---|---|---|---|
Age (years), mean (SD) | 67.5 (15.0) | 66.7 (16.7) | 0.80 |
Male, n (%) | 29 (50) | 29 (48.3) | 0.86 |
ICU, n (%) | Â | Â | 0.79 |
 Medical | 40 (69) | 40 (66.7) |  |
 Surgical | 18 (31) | 20 (33.3) | |
Mechanical ventilation, n (%) | 48 (82.8) | 50 (83.3) | 0.93 |
Vasopressors, n (%) | 45 (77.6) | 47 (78.3) | 0.92 |
Sepsis, n (%) | 37 (63.8) | 32 (53.3) | 0.25 |
APACHE II score, mean (SD) | 24.5 (6.4) | 21.8 (6.9) | 0.027 |
SOFA score, mean (SD) | 12.7 (3.3) | 11.4 (4.0) | 0.058 |
Nonrenal SOFA score, mean (SD) | 9.9 (3.3) | 9.1 (4.1) | 0.21 |
Baseline serum creatinine (mg/dL), mean (SD) | 1.14 (0.44) | 1.03 (0.37) | 0.16 |
Estimated GFR (mL/min/1.73m2), mean (SD)a | 70.31 (28.1) | 69.98 (22.8) | 0.95 |
AKI staging, n (%) | Â | Â | 0.06 |
 1 | 11 (19) | 12 (20) |  |
 2 | 27 (46.6) | 16 (26.7) |  |
 3 | 20 (34.5) | 32 (53.3) |  |
Blood urea nitrogen at enrollment (mg/dL), median (IQR) | 42 (37–78) | 51 (37.5–61.25) | 0.52 |
Serum creatinine at enrollment (mg/dL), median (IQR) | 2 (2–3) | 2.5 (2–3) | 0.88 |
Co-morbidities, n (%) | |||
 Hypertension | 29 (50) | 24 (56.7) | 0.47 |
 Diabetes | 14 (24.1) | 15 (25) | 0.91 |
 Dyslipidemia | 16 (27.6) | 16 (26.7) | 0.91 |
 Ischemic heart disease | 12 (20.7) | 10 (16.7) | 0.58 |
 Malignancy | 12 (20.7) | 8 (13.3) | 0.29 |
 Cerebrovascular disease | 5 (8.6) | 7 (11.7) | 0.58 |
 Chronic liver disease | 10 (17.2) | 11 (18.3) | 0.88 |
Nephrotoxic drugs, n (%) | |||
 Colistin | 5 (8.6) | 10 (16.7) | 0.19 |
 Vancomycin | 1 (1.7) | 1 (1.7) | 0.98 |
 Contrast | 8 (13.8) | 11 (18.3) | 0.50 |
 Aminoglycosides | 2 (3.4) | 2 (3.3) | 0.97 |
 Amphotericin | 2 (3.4) | 0 (0) | 0.15 |
 NSAIDs | 2 (3.4) | 1 (1.7) | 0.54 |
Cardiac surgery, n (%) | 13 (22.4) | 8 (13.3) | 0.20 |
Treatment limitation, n (%)b | 12 (20.7) | 10 (16.7) | 0.58 |
Fluid accumulation at randomization (mL), median (IQR) | 4763 (2837–8515) | 5114 (2050–8803) | 0.84 |
Percentage of fluid overload, median (IQR)c | 9.53 (3.43–19.68) | 7.63 (2.10–12.02) | 0.87 |
Baseline NGAL (ng/mL), median (IQR) | 625 (376–1362) | 860 (447–1204) | 0.63 |
Baseline NT-proBNP (pg/mL), median (IQR) | 4301 (515–35,000) | 5844 (869–10,007) | 0.71 |
Baseline angiopoietin-2 (ng/mL), median (IQR) | 16,784 (8649–35,545) | 22,294 (12539–33,186) | 0.95 |