Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients

Table 2 Estimated micafungin parameters

Parameters	Mean ± SD	Coefficient of variation (%)	Variance	Median
Clearance (l/h)	0.80 ± 0.49	61.78	0.24	0.73
Central volume (l)	16.34 ± 5.87	35.95	34.49	16.34
kcp (h⁻¹)	0.38 ± 0.37	97.76	0.14	0.26
kpc (h⁻¹)	0.32 ± 0.31	96.51	0.09	0.14

Parameter estimates for micafungin from the final two-compartment covariate population pharmacokinetic model
kcp, rate constant for drug distribution from the central to peripheral compartment; kpc, rate constant for drug distribution from the peripheral to central compartment

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