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Table 2 Studies investigating the use of mechanical ventilation in patients experiencing AE-IPF and major outcomes

From: Acute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome?

Study Time frame N MV AE-IPF NIV Ventilator setting ICU mortality Hospital mortality
Molina-Molina et al. [106] 1986–2002 14 14 NR NR NR NR 85% (11/13)
Nava and Rubini [37] 1998 7 7 NR 0 VT 8.3 ml/kg 86% (6/7) NR
Stern et al. [107] 1991–1999 23 23 16 NR VT 8–13 ml/kg 96% (22/23) 96% (22/23)
Blivet et al. [108] 1989–1998 15 15 6 5 NR 73% (11/15) 87% (13/15)
Saydain et al. [109] 1995–2000 38 19 15 7 NR 68% (13/19) 61% (23/38)
Fumeaux et al. [110] 1996–2001 14a 14 NR 11 VT 7–9 ml/kg 100% (14/14) 100% (14/14)
Al-Hameed and Sharma [80] 1998–2000 25 25 25 3 PEEP 7 cmH2O 84% (21/25) 96% (24/25)
Kim et al. [4] 1990–2003 10 9 9 NR NR 78% (7/9) 78% (7/9)
Pitsiou et al. [30] 2001–2005 12 12 NR NR NR 100 (12/12) 100% (12/12)
Rangappa and Moran [112] 1996–2006 24 19 8 NR NR 67% (16/24) 92% (22/24)
Fernandez-Pèrez et al. [113] 2002–2006 30 30 NR NR VT 7–8 ml/kg NR 60% (18/30)
Mollica et al. [114] 2000–2007 34 34 22 19 VT 7.5 ml/kg or PS/PEEP 18/7 cmH2O 100% IMV, 73% NIV 85% (29/34)
Yokoama et al. [85] 1998–2004 11 11 11 11 CPAP 10 cmH2O, PS/PEEP 5/10 cmH2O NR 56% (6/11) (3 months)
Gungor et al. [115] 2000–2007 96 96 NR 28 VT 6-8 ml/kg, PEEP 5–7 cmH2O 64% (61/96) NR
Vianello et al. [116] 2005–2013 18 18 6 18 PEEP 5–8 cmH2O 56% (10/18) NR
Gaudry et al. [117] 2002–2009 22 22 NR 0 VT 5.9 ml/kg, PEEP 7.1 cmH2O 67% (17/22) NR
Aliberti et al. [41] 2004–2009 60 60 24 60 CPAP 8 cmH2O, PS/PEEP 5/15 NR 35% (21/60)
Total   453 428 142 162    
  1. AE-IPF acute exacerbation of idiopathic pulmonary fibrosis, MV mechanical ventilation, NIV noninvasive mechanical ventilation, ICU intensive care unit, NR not reported, V T tidal volume, PEEP positive end-expiratory pressure, PS pressure support, CPAP continuous positive airway pressure
  2. aThree non-IPF