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Table 1 Meta-analyses of the use of high-flow nasal cannulas (HFNCs) in hypoxemic respiratory failure

From: A Systematic Review of the High-flow Nasal Cannula for Adult Patients

Reference

Inclusion criteria

Number of studies

Number of patients

Comparators to the HFNC

Intubation rate

Mortality

Other outcomes

Ni et al. [51]

Adults with PaO2/FiO2 ≤ 300 mmHg OR SpO2 < 92% on 10–12 l/min O2

18

3881

NIV or conventional oxygen therapy

Lower compared to conventional oxygen therapy but similar to NIV

Similar

Lower RR with HFNC compared to both conventional oxygen therapy and NIV. PaO2/FiO2 better than with conventional oxygen therapy.

No difference in ICU LOS.

No effect on PaCO2 or pH

Ou et al. [20]

Adults with acute hypoxemic respiratory failure (PaO2/FiO2 ≤ 300)

6

1892

NIV or conventional oxygen therapy

Lower compared to conventional oxygen therapy in high-risk patients, but similar to NIV

Similar

 

Monro-Somerville [21]

Adults with respiratory failure

9

2507

Conventional oxygen therapy

Similar

Similar

Better tolerance of HFNC

  1. NIV non-invasive ventilation, LOS length of stay, ICU intensive care unit, RR: respiratory rate