From: A Systematic Review of the High-flow Nasal Cannula for Adult Patients
Reference | Inclusion criteria | Number of studies | Number of patients | Comparators to the HFNC | Intubation rate | Mortality | Other outcomes |
---|---|---|---|---|---|---|---|
Ni et al. [51] | Adults with PaO2/FiO2 ≤ 300 mmHg OR SpO2 < 92% on 10–12 l/min O2 | 18 | 3881 | NIV or conventional oxygen therapy | Lower compared to conventional oxygen therapy but similar to NIV | Similar | Lower RR with HFNC compared to both conventional oxygen therapy and NIV. PaO2/FiO2 better than with conventional oxygen therapy. No difference in ICU LOS. No effect on PaCO2 or pH |
Ou et al. [20] | Adults with acute hypoxemic respiratory failure (PaO2/FiO2 ≤ 300) | 6 | 1892 | NIV or conventional oxygen therapy | Lower compared to conventional oxygen therapy in high-risk patients, but similar to NIV | Similar |  |
Monro-Somerville [21] | Adults with respiratory failure | 9 | 2507 | Conventional oxygen therapy | Similar | Similar | Better tolerance of HFNC |