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Table 1 Meta-analyses of the use of high-flow nasal cannulas (HFNCs) in hypoxemic respiratory failure

From: A Systematic Review of the High-flow Nasal Cannula for Adult Patients

Reference Inclusion criteria Number of studies Number of patients Comparators to the HFNC Intubation rate Mortality Other outcomes
Ni et al. [51] Adults with PaO2/FiO2 ≤ 300 mmHg OR SpO2 < 92% on 10–12 l/min O2 18 3881 NIV or conventional oxygen therapy Lower compared to conventional oxygen therapy but similar to NIV Similar Lower RR with HFNC compared to both conventional oxygen therapy and NIV. PaO2/FiO2 better than with conventional oxygen therapy.
No difference in ICU LOS.
No effect on PaCO2 or pH
Ou et al. [20] Adults with acute hypoxemic respiratory failure (PaO2/FiO2 ≤ 300) 6 1892 NIV or conventional oxygen therapy Lower compared to conventional oxygen therapy in high-risk patients, but similar to NIV Similar  
Monro-Somerville [21] Adults with respiratory failure 9 2507 Conventional oxygen therapy Similar Similar Better tolerance of HFNC
  1. NIV non-invasive ventilation, LOS length of stay, ICU intensive care unit, RR: respiratory rate